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Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6 Pt 2
|
pubmed:dateCreated |
1990-9-20
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pubmed:abstractText |
Intravenous infusion of gamma-glutamyl-L-dopa (25 micrograms/kg/min) for 10 h in normal humans caused a natriuresis of 46.5 mmol of sodium without an increase in plasma renin activity and was associated with small but significant falls in blood pressure. In a second study the oral bioavailability of gludopa was estimated in normal subjects and found to be low (less than 2%). The increase in urine dopamine excretion and the natriuretic effect of gludopa were much larger after intravenous infusion than oral dosing.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
0895-7061
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
3
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
126S-129S
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pubmed:dateRevised |
2009-2-24
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pubmed:meshHeading |
pubmed-meshheading:2116808-Absorption,
pubmed-meshheading:2116808-Administration, Oral,
pubmed-meshheading:2116808-Adult,
pubmed-meshheading:2116808-Biological Availability,
pubmed-meshheading:2116808-Blood Pressure,
pubmed-meshheading:2116808-Dihydroxyphenylalanine,
pubmed-meshheading:2116808-Dopamine,
pubmed-meshheading:2116808-Female,
pubmed-meshheading:2116808-Humans,
pubmed-meshheading:2116808-Infusions, Intravenous,
pubmed-meshheading:2116808-Male,
pubmed-meshheading:2116808-Time Factors,
pubmed-meshheading:2116808-Urine
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pubmed:year |
1990
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pubmed:articleTitle |
Effect of prolonged intravenous infusion of gludopa in humans and a preliminary study of its oral bioavailability.
|
pubmed:affiliation |
University Department of Clinical Pharmacology, Royal Infirmary, Edinburgh, Scotland.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Controlled Clinical Trial
|