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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-1-11
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pubmed:abstractText |
Boropinic acid is a natural isopentenyloxycinnamic acid extracted from the aerial parts of Boronia pinnata Sm. (Rutaceae) with soybean 5-lipoxygenase inhibitory activity. In this paper the topical anti-inflammatory activity of boropinic acid and some of its natural and semi-synthetic derivatives was evaluated using the Croton oil ear test in mice as a model of acute inflammation. Some of the tested compounds (15, 17, 19, 20) revealed an effect comparable (ID(50)=0.18÷0.72?mol/cm(2)) to that of the reference drug indomethacin (ID(50)=0.23?mol/cm(2)), a non-steroidal anti-inflammatory drug.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1464-3405
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
769-72
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pubmed:meshHeading |
pubmed-meshheading:21167711-Administration, Topical,
pubmed-meshheading:21167711-Animals,
pubmed-meshheading:21167711-Anti-Inflammatory Agents,
pubmed-meshheading:21167711-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:21167711-Boronic Acids,
pubmed-meshheading:21167711-Croton Oil,
pubmed-meshheading:21167711-Indomethacin,
pubmed-meshheading:21167711-Inflammation,
pubmed-meshheading:21167711-Male,
pubmed-meshheading:21167711-Mice,
pubmed-meshheading:21167711-Rutaceae
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pubmed:year |
2011
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pubmed:articleTitle |
Topical anti-inflammatory activity of boropinic acid and its natural and semi-synthetic derivatives.
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pubmed:affiliation |
Dipartimento di Scienze del Farmaco, Università G. D'Annunzio Chieti-Pescara, Via dei Vestini 31, Chieti Scalo (CH) 66013, Italy. fepifano@unich.it
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pubmed:publicationType |
Journal Article
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