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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2011-7-13
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pubmed:abstractText |
In Alzheimer's disease (AD), microglial activation prompted by the presence of amyloid has been proposed as an important contributor to the neurodegenerative process. Conversely following A? immunization, phagocytic microglia have been implicated in plaque removal, potentially a beneficial effect. We have investigated the effects of A?42 immunization on microglial activation and the relationship with A?42 load in human AD.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AN-1792,
http://linkedlifedata.com/resource/pubmed/chemical/APP protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Alzheimer Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Amyloid beta-Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Amyloid beta-Protein Precursor,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/CD68 antigen, human
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1365-2990
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pubmed:author |
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pubmed:copyrightInfo |
© 2011 The Authors. Neuropathology and Applied Neurobiology © 2011 British Neuropathological Society.
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pubmed:issnType |
Electronic
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
513-24
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pubmed:meshHeading |
pubmed-meshheading:21166690-Aged,
pubmed-meshheading:21166690-Aged, 80 and over,
pubmed-meshheading:21166690-Alzheimer Disease,
pubmed-meshheading:21166690-Alzheimer Vaccines,
pubmed-meshheading:21166690-Amyloid beta-Peptides,
pubmed-meshheading:21166690-Amyloid beta-Protein Precursor,
pubmed-meshheading:21166690-Antigens, CD,
pubmed-meshheading:21166690-Antigens, Differentiation, Myelomonocytic,
pubmed-meshheading:21166690-Brain,
pubmed-meshheading:21166690-Clinical Trials, Phase I as Topic,
pubmed-meshheading:21166690-Female,
pubmed-meshheading:21166690-Humans,
pubmed-meshheading:21166690-Immunohistochemistry,
pubmed-meshheading:21166690-Male,
pubmed-meshheading:21166690-Microglia,
pubmed-meshheading:21166690-Microscopy, Confocal,
pubmed-meshheading:21166690-Middle Aged,
pubmed-meshheading:21166690-Plaque, Amyloid
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pubmed:year |
2011
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pubmed:articleTitle |
Microglial alterations in human Alzheimer's disease following A?42 immunization.
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pubmed:affiliation |
Division of Clinical Neurosciences, School of Medicine, University of Southampton, UK. e.zotova@soton.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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