Linked Life Data

21164262

Source:http://linkedlifedata.com/resource/pubmed/id/21164262

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2010-12-17
pubmed:abstractText
The disturbance of the hypothalamic-pituitary- adrenal axis characteristic of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD) is likely to affect brain development, yet neuroanatomic work is only beginning. Fetal hyperandrogenemia in 46, XX 21-OHD leads to masculinized brain organization and, consequently, at later stages of development, to masculinized gender-related behavior and cognitive function, including, although relatively uncommonly, gender identity. Genital masculinization as well as its surgical treatment has implications for social stigmatization and sexual functioning. CAH-associated electrolyte crises in infancy and later may result in severe cognitive impairment. Psychiatric disorders are somewhat increased, especially in patients with severe degrees of CAH.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1662-2979
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 S. Karger AG, Basel.
pubmed:issnType
Electronic
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
88-95
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Brain development and cognitive, psychosocial, and psychiatric functioning in classical 21-hydroxylase deficiency.
pubmed:affiliation
NYS Psychiatric Institute/Department of Psychiatry, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA. meyerb@childpsych.columbia.edu
pubmed:publicationType
Journal Article, Review