Linked Life Data

21164256

Source:http://linkedlifedata.com/resource/pubmed/id/21164256

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2010-12-17
pubmed:abstractText
The adrenal gland is formed by the adrenal medulla and the adrenal cortex. Both tissues descend from different origins during embryonal development. While the chromaffin cells are derived from the neural crest, the adrenocortical cells stem from a cell condensation in the celomic epithelium. Already during adrenal organogenesis, close interactions between the two tissue types are necessary for the differentiation, morphogenesis and survival of the adrenal gland. Moreover, the communication between the chromaffin and adrenocortical cells ensures a regular function of the adult adrenal gland including the regulation of hormone synthesis and responses to stress. This is even more important since the cortical-chromaffin crosstalk is also relevant for the pathogenesis of different diseases. In the past decade, significant progress in the understanding of the cortical-chromaffin communication has been made. Here, we summarize the insights gained from in vitro studies, from animal models and from clinical observations.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1662-2979
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 S. Karger AG, Basel.
pubmed:issnType
Electronic
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
28-37
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Update on the corticomedullary interaction in the adrenal gland.
pubmed:affiliation
Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Moorenstrasse 5, Duesseldorf, Germany.
pubmed:publicationType
Journal Article, Review