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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2011-1-28
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pubmed:abstractText |
The A?(25-35) fraction mimics the toxic effects of the complete peptide A?(1-42) because this decapeptide is able to cause memory impairment and neurodegenerative events. Recent evidence has shown that the injection of A?(25-35) into the temporal cortex (TCx) of the rat increases the nitric oxide (NO) pathways with several consequences, such as neuronal loss in rats. Our aim was to investigate the effects of each NOS isoform by the prior injection of NOS inhibitors before the injection of the A?(25-35). One month after the treatment, the animals were tested for their spatial memory in the radial maze. The hippocampus (Hp) and TCx were assessed for NO production, nitration of proteins (3-NT), astrocytosis (GFAP), and neuronal loss. Our findings show a significant impairment in the memory caused by A?25-35 injection. In contrast NOS inhibitors plus A?25-35 cause a protection yielding a high performance in the memory test and reduction of cell damage in the TCx and the Hp. Particularly, iNOS is the major source of NO and related to the inflammatory response leading to the memory deficits. The inhibition of iNOS is an important target for neuronal protection against the toxicity of the A?25-35 over the long term.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3-nitrotyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/7-nitroindazole,
http://linkedlifedata.com/resource/pubmed/chemical/Amyloid beta-Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Glial Fibrillary Acidic Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Guanidines,
http://linkedlifedata.com/resource/pubmed/chemical/Indazoles,
http://linkedlifedata.com/resource/pubmed/chemical/NG-Nitroarginine Methyl Ester,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrates,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Nos2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/amyloid beta-protein (25-35),
http://linkedlifedata.com/resource/pubmed/chemical/pimagedine
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1873-5177
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
98
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
67-75
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pubmed:meshHeading |
pubmed-meshheading:21163295-Amyloid beta-Peptides,
pubmed-meshheading:21163295-Animals,
pubmed-meshheading:21163295-Enzyme Inhibitors,
pubmed-meshheading:21163295-Glial Fibrillary Acidic Protein,
pubmed-meshheading:21163295-Guanidines,
pubmed-meshheading:21163295-Hippocampus,
pubmed-meshheading:21163295-Indazoles,
pubmed-meshheading:21163295-Male,
pubmed-meshheading:21163295-Maze Learning,
pubmed-meshheading:21163295-Memory,
pubmed-meshheading:21163295-Memory Disorders,
pubmed-meshheading:21163295-NG-Nitroarginine Methyl Ester,
pubmed-meshheading:21163295-Nitrates,
pubmed-meshheading:21163295-Nitric Oxide Synthase,
pubmed-meshheading:21163295-Nitric Oxide Synthase Type II,
pubmed-meshheading:21163295-Peptide Fragments,
pubmed-meshheading:21163295-Rats,
pubmed-meshheading:21163295-Rats, Wistar,
pubmed-meshheading:21163295-Temporal Lobe,
pubmed-meshheading:21163295-Tyrosine
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pubmed:year |
2011
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pubmed:articleTitle |
The role of NOS in the impairment of spatial memory and damaged neurons in rats injected with amyloid beta 25-35 into the temporal cortex.
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pubmed:affiliation |
Laboratorio de Neurofarmacología, Facultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, Puebla 72570, Mexico.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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