Source:http://linkedlifedata.com/resource/pubmed/id/21160623
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2010-12-16
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| pubmed:abstractText |
Peroxisome proliferator activated receptor-? (PPAR?), a transcription factor of the nuclear receptor superfamily plays a significant role in colorectal cancer pathogenesis. In most experimental systems PPAR? activation has tumor suppressing effects in the colon. PPAR? is regulated at multiple levels by the ubiquitin-proteasome system (UPS). At a first level, UPS regulates PPAR? transcription. This regulation involves both PPAR? transcription specific factors and the general transcription machinery. At a second level UPS regulates PPAR? and its co-factors themselves, as PPAR? and many co-factors are proteasome substrates. At a third level of regulation, transduction pathways working in parallel but also having interrelations with PPAR? are regulated by the UPS, creating a network of regulation in the colorectal carcinogenesis-related pathways that are under UPS control. Activation of PPAR? transcription by direct pharmacologic activators and by stabilization of its molecule by proteasome inhibitors could be strategies to be exploited in colorectal cancer treatment.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:status |
PubMed-not-MEDLINE
|
| pubmed:month |
May
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| pubmed:issn |
1948-5204
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:day |
15
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| pubmed:volume |
2
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
235-41
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| pubmed:year |
2010
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| pubmed:articleTitle |
Peroxisome proliferator activated receptor-? and the ubiquitin-proteasome system in colorectal cancer.
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| pubmed:affiliation |
Ioannis A Voutsadakis, Department of Medical Oncology, University Hospital of Larissa, Larissa 41110, Greece.
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| pubmed:publicationType |
Journal Article
|