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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
62
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pubmed:dateCreated |
2010-12-16
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pubmed:abstractText |
The use of a prostate-specific antigen (PSA) test to screen for prostate cancer is controversial because of its modest predictive value and the potential overdiagnosis and over-treatment of the disease. A research article in this issue of Science Translational Medicine describes single-nucleotide polymorphisms (SNPs) in or near six genes that are independently associated with serum PSA concentrations and that help to explain interindividual PSA variation. Three of these SNPs are also associated with prostate biopsy outcomes. These findings are an important step toward incorporating genetic markers into PSA screening, with the ultimate goal of devising personalized PSA tests for use in the clinic.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/FGFR2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Genetic Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Kallikreins,
http://linkedlifedata.com/resource/pubmed/chemical/Prostate-Specific Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Prostatic Secretory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Fibroblast Growth...,
http://linkedlifedata.com/resource/pubmed/chemical/T-Box Domain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TBX3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TERT protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Telomerase,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/beta-microseminoprotein,
http://linkedlifedata.com/resource/pubmed/chemical/kallikrein-related peptidase 3...
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1946-6242
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
62ps55
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pubmed:dateRevised |
2011-6-15
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pubmed:meshHeading |
pubmed-meshheading:21160075-Early Detection of Cancer,
pubmed-meshheading:21160075-Genetic Markers,
pubmed-meshheading:21160075-Humans,
pubmed-meshheading:21160075-Kallikreins,
pubmed-meshheading:21160075-Male,
pubmed-meshheading:21160075-Polymorphism, Single Nucleotide,
pubmed-meshheading:21160075-Prostate-Specific Antigen,
pubmed-meshheading:21160075-Prostatic Neoplasms,
pubmed-meshheading:21160075-Prostatic Secretory Proteins,
pubmed-meshheading:21160075-Receptor, Fibroblast Growth Factor, Type 2,
pubmed-meshheading:21160075-T-Box Domain Proteins,
pubmed-meshheading:21160075-Telomerase,
pubmed-meshheading:21160075-Tumor Markers, Biological
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pubmed:year |
2010
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pubmed:articleTitle |
Personalized prostate cancer screening: improving PSA tests with genomic information.
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pubmed:affiliation |
Department of Epidemiology and Biostatistics, Institute for Human Genetics, and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA. jwitte@ucsf.edu
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pubmed:publicationType |
Journal Article,
Comment,
Research Support, N.I.H., Extramural
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