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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-1-6
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pubmed:abstractText |
The regulation of neutrophil recruitment, activation, and disposal is pivotal for circumscribed inflammation. SHP1(Y208N/Y208N) mutant mice develop severe cutaneous inflammatory disease that is IL-1R dependent. Genetic reduction in neutrophil numbers and neutrophilic responses to infection is sufficient to prevent the spontaneous initiation of this disease. Neutrophils from SHP1(Y208N/Y208N) mice display increased pro-IL-1? production due to altered responses to MyD88-dependent and MyD88-independent signals. The IL-1R-dependent inflammatory disease in SHP1(Y208N/Y208N) mice develops independently of caspase 1 and proteinase 3 and neutrophil elastase. In response to Fas ligand, a caspase 1-independent inducer of IL-1? production, neutrophils from SHP1(Y208N/Y208N) mice produce elevated levels of IL-1? but display reduced caspase 3 and caspase 7 activation. In neutrophils deficient in SHP1, IL-1? induces high levels of pro-IL-1? suggesting the presence of a paracrine IL-1? loop. These data indicate that the neutrophil- and IL-1-dependent disease in SHP1(Y208N/Y208N) mice is a consequence of loss of negative regulation of TLR and IL-1R signaling.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1550-6606
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
186
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1131-9
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pubmed:meshHeading |
pubmed-meshheading:21160041-Animals,
pubmed-meshheading:21160041-Autoimmune Diseases,
pubmed-meshheading:21160041-Bone Marrow Cells,
pubmed-meshheading:21160041-Humans,
pubmed-meshheading:21160041-Inflammation Mediators,
pubmed-meshheading:21160041-Interleukin-1beta,
pubmed-meshheading:21160041-Mice,
pubmed-meshheading:21160041-Mice, Inbred C57BL,
pubmed-meshheading:21160041-Mice, Knockout,
pubmed-meshheading:21160041-Mice, Mutant Strains,
pubmed-meshheading:21160041-Neutrophils,
pubmed-meshheading:21160041-Paracrine Communication,
pubmed-meshheading:21160041-Protein Tyrosine Phosphatase, Non-Receptor Type 6,
pubmed-meshheading:21160041-Severity of Illness Index,
pubmed-meshheading:21160041-Signal Transduction,
pubmed-meshheading:21160041-Skin Diseases,
pubmed-meshheading:21160041-Toll-Like Receptors
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pubmed:year |
2011
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pubmed:articleTitle |
Neutrophils require SHP1 to regulate IL-1? production and prevent inflammatory skin disease.
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pubmed:affiliation |
Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia. croker@wehi.edu.au
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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