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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2011-4-5
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pubmed:abstractText |
Acute pancreatitis (AP) can result in pancreatic necrosis and inflammation, with subsequent multi-organ failure. AP is associated with increased neutrophil recruitment and a rise in pro-inflammatory cytokines such as TNF?. Pretreatment with haemin, results in recruitment of haem-oxygenase-1 (HO-1)(+) macrophages and protects against experimental pancreatitis. It is not clear whether modulation of HO-1 after onset of disease has a protective role. In this study, we tested the utility of Panhematin, a water-soluble haemin formulation, in activating and inducing pancreatic HO-1, and as a therapeutic agent in treating mouse acute pancreatitis.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1468-3288
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
671-9
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pubmed:meshHeading |
pubmed-meshheading:21159893-Acute Disease,
pubmed-meshheading:21159893-Animals,
pubmed-meshheading:21159893-Arginine,
pubmed-meshheading:21159893-Carbon Monoxide,
pubmed-meshheading:21159893-Chemokine CXCL1,
pubmed-meshheading:21159893-Cytokines,
pubmed-meshheading:21159893-Disease Models, Animal,
pubmed-meshheading:21159893-Drug Administration Schedule,
pubmed-meshheading:21159893-Drug Evaluation, Preclinical,
pubmed-meshheading:21159893-Female,
pubmed-meshheading:21159893-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:21159893-Heme Oxygenase-1,
pubmed-meshheading:21159893-Hemin,
pubmed-meshheading:21159893-Inflammation Mediators,
pubmed-meshheading:21159893-Liver,
pubmed-meshheading:21159893-Mice,
pubmed-meshheading:21159893-Mice, Inbred Strains,
pubmed-meshheading:21159893-Mice, Transgenic,
pubmed-meshheading:21159893-Pancreas,
pubmed-meshheading:21159893-Pancreatitis,
pubmed-meshheading:21159893-Spleen,
pubmed-meshheading:21159893-Up-Regulation
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pubmed:year |
2011
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pubmed:articleTitle |
Panhematin provides a therapeutic benefit in experimental pancreatitis.
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pubmed:affiliation |
University of Michigan Medical School, Department of Molecular & Integrative Physiology, Ann Arbor, Michigan, USA. aidah@stanford.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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