Linked Life Data

21159410

Source:http://linkedlifedata.com/resource/pubmed/id/21159410

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-1-25
pubmed:abstractText
Novel clarithromycin derivatives with C-4? elongated arylalkyl groups were designed, synthesized and evaluated to probe the effect of different lengths of their C-4? side chains on the activity against resistant bacterial strains. These derivatives had excellent activity against erythromycin-susceptible Streptococcus pneumoniae, Streptococcus aureus or Streptococcus pyogenes and some of them exhibited greatly improved activity against erythromycin-resistant strains. Compounds 18 and 16, which had the C-4? elongated arylalkyl groups with eight atoms from the 4?-oxygen atom to the terminal benzene ring, were the most effective against S. pneumoniae expressing the erm gene and the erm and mef genes. In contrast, the most potent compounds 3, 5, 9, 17 and 18 against S. pneumoniae expressing the mef gene had C-4? elongated arylalkyl groups with three to eight atoms between the 4?-oxygen atom and the terminal aromatic ring.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1768-3254
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier Masson SAS. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
556-66
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Synthesis and antibacterial evaluation of novel clarithromycin derivatives with C-4? elongated arylalkyl groups against macrolide-resistant strains.
pubmed:affiliation
Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, Jinan 250012, PR China. mashutao@sdu.edu.cn
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't