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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4362
|
| pubmed:dateCreated |
1978-11-29
|
| pubmed:abstractText |
Owl monkeys were inoculated intracerebrally, subcutaneously, and intravenously with JC, BK, or SV40 virus. Two of four adult owl monkeys inoculated with JC virus, a human polyomavirus, developed brain tumors at 16 and 25 months after inoculation, respectively. A grade 3 to grade 4 astrocytoma (resembling a human glioblastoma multiforme) was found in the left cerebral hemisphere and brainstem of one monkey. The second monkey developed a malignant tumor in the left cerebral hemisphere containing both glial and neuronal cell types. Impression smears prepared from unfixed tissue of this tumor showed cells that contained polyomavirus T antigen. Virion antigens were not detected. Tumor cells cultured in vitro also contained T antigen but were negative for virion antigen. Infectious virus was not isolated from extracts of this tumor.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0036-8075
|
| pubmed:author |
pubmed-author:FuccilloD ADA,
pubmed-author:GravellMM,
pubmed-author:HouffS ASA,
pubmed-author:LondonW TWT,
pubmed-author:MaddenD LDL,
pubmed-author:OhashiTT,
pubmed-author:PadgettB LBL,
pubmed-author:PalmerA EAE,
pubmed-author:SeverJ LJL,
pubmed-author:WalkerD LDL,
pubmed-author:WallenW CWC,
pubmed-author:ZuRheinG MGM
|
| pubmed:issnType |
Print
|
| pubmed:day |
29
|
| pubmed:volume |
201
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1246-9
|
| pubmed:dateRevised |
2007-3-19
|
| pubmed:meshHeading | |
| pubmed:year |
1978
|
| pubmed:articleTitle |
Brain tumors in owl monkeys inoculated with a human polyomavirus (JC virus).
|
| pubmed:publicationType |
Journal Article
|