Source:http://linkedlifedata.com/resource/pubmed/id/21157511
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2010-12-15
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| pubmed:abstractText |
Controversial observations have been published on the association of the cytotoxic T lymphocyte associated antigen gene's variants with rheumatoid arthritis (RA). After genotyping 428 patients and 230 matched controls, the prevalence of the CT60(?)G allele was more frequent in RF- and/or anti-CCP-seropositive RApatients, compared to the healthy controls (P < .001). Regression analysis revealed that the CT60(?)G allele is a possible predisposing factor for RA in these subgroups. No accumulation of the +49(?)G allele was found among patients, and this variant was not found to correlate with RA. Assaying the possible genotype variations, the +49(?)G-CT60(?)G allelic combination was accumulated in seropositive RA-subtypes, and was associated with the risk of RA (OR = 1.73, P = .001 for the whole RA-population). Although the +49(?)G allele did not mean a predisposition to RA alone, in combination with CT60(?)G it, also conferred risk, suggesting that the +49A/G variant is associated with the risk of RA only in certain haplotypes.
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| pubmed:language |
eng
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| pubmed:status |
PubMed-not-MEDLINE
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| pubmed:author | |
| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
285974
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| pubmed:articleTitle |
Cytotoxic T lymphocyte-Associated Antigen +49G Variant Confers Risk for Anti-CCP- and Rheumatoid Factor-Positive Type of Rheumatoid Arthritis Only in Combination with CT60G Allele.
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| pubmed:affiliation |
Department of Medical Genetics and Child Development, University of Pecs, Pecs 7624, Hungary.
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| pubmed:publicationType |
Journal Article
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