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rdf:type |
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lifeskim:mentions |
umls-concept:C0001792,
umls-concept:C0019878,
umls-concept:C0032659,
umls-concept:C0085201,
umls-concept:C0332281,
umls-concept:C0439841,
umls-concept:C1328319,
umls-concept:C1521761,
umls-concept:C1547135,
umls-concept:C1547139,
umls-concept:C1561560,
umls-concept:C1561561
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pubmed:issue |
2
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pubmed:dateCreated |
2011-1-31
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pubmed:abstractText |
The ankle brachial index (ABI) is an indicator of lower extremity peripheral arterial disease (PAD) and a predictor of atherothrombosis. ApoA-I and HDL are associated with PAD, in humans. Homocysteine influences the liver expression of ApoA-I and decreases its blood level and HDL in genetic mice models. We aimed therefore to evaluate whether homocysteine and its nutritional determinants, folate and vitamin B12 are associated with ABI by influencing HDL metabolism, in an ambulatory elderly population.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1879-1484
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
214
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
480-5
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pubmed:meshHeading |
pubmed-meshheading:21156318-Age Factors,
pubmed-meshheading:21156318-Aged,
pubmed-meshheading:21156318-Aged, 80 and over,
pubmed-meshheading:21156318-Ankle Brachial Index,
pubmed-meshheading:21156318-Apolipoprotein A-I,
pubmed-meshheading:21156318-Biological Markers,
pubmed-meshheading:21156318-Cholesterol, HDL,
pubmed-meshheading:21156318-Female,
pubmed-meshheading:21156318-Folic Acid,
pubmed-meshheading:21156318-Homocysteine,
pubmed-meshheading:21156318-Humans,
pubmed-meshheading:21156318-Independent Living,
pubmed-meshheading:21156318-Male,
pubmed-meshheading:21156318-Methylmalonic Acid,
pubmed-meshheading:21156318-Middle Aged,
pubmed-meshheading:21156318-Particle Size,
pubmed-meshheading:21156318-Peripheral Arterial Disease,
pubmed-meshheading:21156318-Regression Analysis,
pubmed-meshheading:21156318-Risk Assessment,
pubmed-meshheading:21156318-Risk Factors,
pubmed-meshheading:21156318-Sicily,
pubmed-meshheading:21156318-Vitamin B 12,
pubmed-meshheading:21156318-Walking
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pubmed:year |
2011
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pubmed:articleTitle |
Homocysteine is a determinant of ApoA-I and both are associated with ankle brachial index, in an ambulatory elderly population.
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pubmed:affiliation |
Inserm U954, Medical Faculty and CHU of Nancy, University Henri Poincaré, Nancy, France. rm.rodriguez@chu-nancy.fr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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