Linked Life Data

21156221

Source:http://linkedlifedata.com/resource/pubmed/id/21156221

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-1-25
pubmed:abstractText
Argyrolobium roseum (Papilionaceae) is a sexually reproducing, rare, annual herb that grows in tropical and sub-temperate tracts of the north-western Himalayan region of the Indian subcontinent. The present investigation was carried out to study the immunomodulatory properties of this herb in well established experimental models. For preliminary pharmacological activity evaluation, we first studied the effect of aqueous fraction (KA-134) of A. roseum on humoral and cell mediated immune responses and found that KA-134 dose dependently suppressed the antibody titre and delayed type hypersensitivity reaction. Inspired by the results, we further fractionated KA-134 which yielded pinitol, which on further immunomodulatory studies resulted in highly significant inhibition of CD3, CD19, CD4 and CD8 count and Th1/Th2 cytokines expression in splenocytes. Pinitol was also found to be safe when tested against cell viability assays (in vitro and in vivo). Based on the data, it can be suggested that pinitol is a potent and non-toxic immunosuppressor, which can be further explored for the development of potent immunosuppressor.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1878-1705
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier B.V. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
286-91
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
The immunosuppressive effects of Agyrolobium roseum and pinitol in experimental animals.
pubmed:affiliation
Cell Biology Laboratory, Department of Pharmacology, Indian Institute of Integrative Medicine, Jammu Tawi 180001, Jammu & Kashmir, India. prashant.rrl@gmail.com
pubmed:publicationType
Journal Article