Identification of HLA-G*01:17, a new allele possibly generated by an interloci gene conversion event involving exon 3 of HLA-B.

Source:http://linkedlifedata.com/resource/pubmed/id/21156191

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Authors

Jay P, Plummer FA, Van Domselaar G, Brunham R, Czarnecki C, Embreé J

Abstract

HLA-G*01:17 was discovered in a woman of Kenyan descent who was enrolled in a mother-to-child HIV-1 transmission cohort. The new allele was identical to HLA-G*01:06 at exons 2, 3, and 4 with the exception of a base pair substitution at codon 169 (CAC ? CGC) resulting in a coding change from histidine to arginine and codon 171 (TAC ? CAC), resulting in turn in a coding change from tyrosine to histidine. The World Health Organization (WHO) Nomenclature Committee has named this allele HLA-G*01:17.

PMID
21156191

Publication types

Research Support, Non-U.S. Gov't