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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1990-8-30
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pubmed:abstractText |
The preparation and biological evaluation of a series of 7 beta-[2-(2-aminothiazol-4-yl)-2(Z)-methoximinoacetamido]cep halosporins, substituted at the 3'-position with monocyclic or bicyclic nitrogen-containing heterocycles are described. The resulting family of parenteral compounds displays a broad spectrum of antibacterial activity. Some compounds exhibit a similar level of Gram-negative activity to that of the "third-generation" cephalosporins with increased staphylococcal activity. The in vitro and in vivo antimicrobial activity, structure-activity relationships, beta-lactamase stability, and in vitro and in vivo pharmacological evaluations are presented.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-2623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
2114-21
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:2115587-Animals,
pubmed-meshheading:2115587-Blood Pressure,
pubmed-meshheading:2115587-Cephalosporins,
pubmed-meshheading:2115587-Chemical Phenomena,
pubmed-meshheading:2115587-Chemistry,
pubmed-meshheading:2115587-Dogs,
pubmed-meshheading:2115587-Enterobacter,
pubmed-meshheading:2115587-Escherichia coli,
pubmed-meshheading:2115587-Female,
pubmed-meshheading:2115587-Guinea Pigs,
pubmed-meshheading:2115587-Half-Life,
pubmed-meshheading:2115587-Heart Rate,
pubmed-meshheading:2115587-Klebsiella pneumoniae,
pubmed-meshheading:2115587-Macaca mulatta,
pubmed-meshheading:2115587-Male,
pubmed-meshheading:2115587-Mice,
pubmed-meshheading:2115587-Molecular Structure,
pubmed-meshheading:2115587-Parasympatholytics,
pubmed-meshheading:2115587-Pseudomonas aeruginosa,
pubmed-meshheading:2115587-Rats,
pubmed-meshheading:2115587-Serratia marcescens,
pubmed-meshheading:2115587-Staphylococcus aureus,
pubmed-meshheading:2115587-Streptococcus,
pubmed-meshheading:2115587-Structure-Activity Relationship,
pubmed-meshheading:2115587-beta-Lactamases
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pubmed:year |
1990
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pubmed:articleTitle |
Synthesis and biological evaluation of a series of parenteral 3'-quaternary ammonium cephalosporins.
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pubmed:affiliation |
Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285.
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pubmed:publicationType |
Journal Article
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