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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2010-12-14
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pubmed:abstractText |
Osteosarcoma is the most common primary malignancy of bone with poorly characterized molecular pathways important in its pathogenesis. Increasing evidence indicates that elevated lipid biosynthesis is a characteristic feature of cancer. We sought to investigate the role of lysophosphatidic acid acyltransferase ? (LPAAT?, aka, AGPAT2) in regulating the proliferation and growth of human osteosarcoma cells. LPAAT? can generate phosphatidic acid, which plays a key role in lipid biosynthesis as well as in cell proliferation and survival. Although elevated expression of LPAAT? has been reported in several types of human tumors, the role of LPAAT? in osteosarcoma progression has yet to be elucidated.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
pubmed-author:Bai-ChengHeH,
pubmed-author:BiYangY,
pubmed-author:GaoJian-LiJL,
pubmed-author:GaoYanhongY,
pubmed-author:HaydonRex CRC,
pubmed-author:HeTong-ChuanTC,
pubmed-author:HuNingN,
pubmed-author:HuangEnyiE,
pubmed-author:KeYangY,
pubmed-author:KimStephanie HSH,
pubmed-author:LiMiM,
pubmed-author:LiangChenC,
pubmed-author:LiuXingX,
pubmed-author:LuoJinyongJ,
pubmed-author:LuoXiaojiX,
pubmed-author:LutherGauravG,
pubmed-author:LuuHue HHH,
pubmed-author:RastegarFarbodF,
pubmed-author:SeckMM,
pubmed-author:ShenJikunJ,
pubmed-author:ShenaqDeanaD,
pubmed-author:ShiQiongQ,
pubmed-author:WagnerEric RER,
pubmed-author:WangLinyuanL,
pubmed-author:WeiJiangJ,
pubmed-author:ZuoGuo-WeiGW
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e14182
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pubmed:meshHeading |
pubmed-meshheading:21152068-Acyltransferases,
pubmed-meshheading:21152068-Bone Neoplasms,
pubmed-meshheading:21152068-Cell Line, Tumor,
pubmed-meshheading:21152068-Cell Proliferation,
pubmed-meshheading:21152068-Cell Survival,
pubmed-meshheading:21152068-Disease Progression,
pubmed-meshheading:21152068-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:21152068-Gentian Violet,
pubmed-meshheading:21152068-Humans,
pubmed-meshheading:21152068-Lipids,
pubmed-meshheading:21152068-Neoplasm Metastasis,
pubmed-meshheading:21152068-Osteosarcoma,
pubmed-meshheading:21152068-Phenotype,
pubmed-meshheading:21152068-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:21152068-Tetrazolium Salts,
pubmed-meshheading:21152068-Thiazoles
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pubmed:year |
2010
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pubmed:articleTitle |
Lysophosphatidic acid acyltransferase ? (LPAAT?) promotes the tumor growth of human osteosarcoma.
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pubmed:affiliation |
Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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