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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2010-12-14
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pubmed:abstractText |
Over-activation of TGF? signaling pathway and uncontrolled cell proliferation of hepatic stellate cells (HSCs) play pivotal roles in liver fibrogenesis, while the protein serine/threonine phosphatase PP2C? was reported to negatively regulate TGF? signaling pathway and cell cycle. Our study aimed to investigate the role of PP2C? in liver fibrogenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e14230
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pubmed:meshHeading |
pubmed-meshheading:21151953-Actins,
pubmed-meshheading:21151953-Animals,
pubmed-meshheading:21151953-Cell Cycle,
pubmed-meshheading:21151953-Enzyme Activation,
pubmed-meshheading:21151953-Fibrosis,
pubmed-meshheading:21151953-Hepatic Stellate Cells,
pubmed-meshheading:21151953-Humans,
pubmed-meshheading:21151953-Liver,
pubmed-meshheading:21151953-Mice,
pubmed-meshheading:21151953-Phosphoprotein Phosphatases,
pubmed-meshheading:21151953-Phosphorylation,
pubmed-meshheading:21151953-Rats,
pubmed-meshheading:21151953-Rats, Sprague-Dawley,
pubmed-meshheading:21151953-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:21151953-Saponins,
pubmed-meshheading:21151953-Signal Transduction
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pubmed:year |
2010
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pubmed:articleTitle |
Activation of protein serine/threonine phosphatase PP2C? efficiently prevents liver fibrosis.
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pubmed:affiliation |
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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