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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0016030,
umls-concept:C0022646,
umls-concept:C0032659,
umls-concept:C0076930,
umls-concept:C0086022,
umls-concept:C0221908,
umls-concept:C0332307,
umls-concept:C0442335,
umls-concept:C0596570,
umls-concept:C0851285,
umls-concept:C1136031,
umls-concept:C1533691,
umls-concept:C1705099
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pubmed:dateCreated |
2010-12-14
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pubmed:abstractText |
Lentiviral constructs reportedly can integrate into the genome of non-dividing, terminally differentiated cells and dividing cells, for long-term gene expression. This investigation tested whether a third generation lentiviral-mediated small interfering RNA (siRNA) delivered into renal epithelial and fibroblast cells against type II transforming growth factor-beta receptor (siRNA-TBRII) could better attenuate renal fibrogenesis in comparison with a non-lentiviral construct.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1110-7251
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
2010
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
859240
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pubmed:meshHeading |
pubmed-meshheading:21151672-Actins,
pubmed-meshheading:21151672-Animals,
pubmed-meshheading:21151672-Base Sequence,
pubmed-meshheading:21151672-Epithelial Cells,
pubmed-meshheading:21151672-Fibroblasts,
pubmed-meshheading:21151672-Fibrosis,
pubmed-meshheading:21151672-Genetic Vectors,
pubmed-meshheading:21151672-Green Fluorescent Proteins,
pubmed-meshheading:21151672-HEK293 Cells,
pubmed-meshheading:21151672-Humans,
pubmed-meshheading:21151672-Kidney,
pubmed-meshheading:21151672-Lentivirus,
pubmed-meshheading:21151672-Protein-Serine-Threonine Kinases,
pubmed-meshheading:21151672-RNA Interference,
pubmed-meshheading:21151672-Rats,
pubmed-meshheading:21151672-Receptors, Transforming Growth Factor beta,
pubmed-meshheading:21151672-Suppression, Genetic,
pubmed-meshheading:21151672-Transcription, Genetic,
pubmed-meshheading:21151672-Transfection
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pubmed:year |
2010
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pubmed:articleTitle |
Lentiviral-mediated RNA interference against TGF-beta receptor type II in renal epithelial and fibroblast cell populations in vitro demonstrates regulated renal fibrogenesis that is more efficient than a nonlentiviral vector.
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pubmed:affiliation |
Centre for Kidney Disease Research, School of Medicine, The University of Queensland at Princess Alexandra Hospital, Brisbane, QLD 4102, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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