Linked Life Data

21151033

Source:http://linkedlifedata.com/resource/pubmed/id/21151033

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-12-23
pubmed:abstractText
During their development, B and T cells with self-reactive antigen receptors are generally deleted from the repertoire to avoid autoimmune diseases. Paradoxically, innate-like B-1 cells in mice are positively selected for self-reactivity and form a pool of long-lived, self-renewing B cells that produce most of the circulating natural IgM antibodies. This Review provides an overview of the developmental processes that shape the B-1 cell pool in mice, outlines the functions of B-1 cells in both the steady state and during host defence, and discusses possible functional B-1 cell homologues that exist in humans.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1474-1741
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
34-46
pubmed:dateRevised
2011-10-18
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
The double life of a B-1 cell: self-reactivity selects for protective effector functions.
pubmed:affiliation
Center for Comparative Medicine, University of California, Davis, California 95616, USA. nbaumgarth@ucdavis.edu
pubmed:publicationType
Journal Article, Review, Research Support, N.I.H., Extramural