rdf:type |
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lifeskim:mentions |
|
pubmed:issue |
6
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pubmed:dateCreated |
2011-1-13
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pubmed:abstractText |
CaV1.3 L-type channels control inner hair cell (IHC) sensory and sinoatrial node (SAN) function, and excitability in central neurons by means of their low-voltage activation and inactivation properties. In SAN cells CaV1.3 inward calcium current (ICa) inactivates rapidly whereas in IHCs inactivation is slow. A candidate suggested in slowing CaV1.3 channel inactivation is the presynaptically located ribbon-synapse protein RIM that is expressed in immature IHCs in presynaptic compartments also expressing CaV1.3 channels. CaV1.3 channel gating is also modulated by an intramolecular C-terminal mechanism. This mechanism was elicited during analysis of human C-terminal splice variants that differ in the length of their C-terminus and that modulates the channel's negative activation range and slows calcium-dependent inactivation.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21150316-10929716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21150316-11285265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21150316-11487617,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21150316-11581302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21150316-12700358,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/21150316-18947822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21150316-19710324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21150316-19726659,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21150316-20139964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21150316-20363327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21150316-21131953
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1933-6969
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pubmed:author |
|
pubmed:issnType |
Electronic
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
523-5
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pubmed:dateRevised |
2011-7-28
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pubmed:meshHeading |
pubmed-meshheading:21150316-Animals,
pubmed-meshheading:21150316-Calcium Channels, L-Type,
pubmed-meshheading:21150316-Calcium Signaling,
pubmed-meshheading:21150316-Humans,
pubmed-meshheading:21150316-Ion Channel Gating,
pubmed-meshheading:21150316-Kinetics,
pubmed-meshheading:21150316-Membrane Potentials,
pubmed-meshheading:21150316-Mice,
pubmed-meshheading:21150316-Mice, Knockout,
pubmed-meshheading:21150316-Protein Conformation,
pubmed-meshheading:21150316-Structure-Activity Relationship
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pubmed:articleTitle |
Impact of gating modulation in CaV1.3 L-type calcium channels.
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pubmed:affiliation |
Pharmacology and Toxicology, Institute of Pharmacy, University of Innsbruck, Innsbruck, Austria. alexandra.koschak@uibk.ac.at
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pubmed:publicationType |
Journal Article,
Review
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