Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2011-1-13
pubmed:abstractText
CaV1.3 L-type channels control inner hair cell (IHC) sensory and sinoatrial node (SAN) function, and excitability in central neurons by means of their low-voltage activation and inactivation properties. In SAN cells CaV1.3 inward calcium current (ICa) inactivates rapidly whereas in IHCs inactivation is slow. A candidate suggested in slowing CaV1.3 channel inactivation is the presynaptically located ribbon-synapse protein RIM that is expressed in immature IHCs in presynaptic compartments also expressing CaV1.3 channels. CaV1.3 channel gating is also modulated by an intramolecular C-terminal mechanism. This mechanism was elicited during analysis of human C-terminal splice variants that differ in the length of their C-terminus and that modulates the channel's negative activation range and slows calcium-dependent inactivation.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/21150316-10929716, http://linkedlifedata.com/resource/pubmed/commentcorrection/21150316-11285265, http://linkedlifedata.com/resource/pubmed/commentcorrection/21150316-11487617, http://linkedlifedata.com/resource/pubmed/commentcorrection/21150316-11581302, http://linkedlifedata.com/resource/pubmed/commentcorrection/21150316-12700358, http://linkedlifedata.com/resource/pubmed/commentcorrection/21150316-14514878, http://linkedlifedata.com/resource/pubmed/commentcorrection/21150316-15486420, http://linkedlifedata.com/resource/pubmed/commentcorrection/21150316-15689540, http://linkedlifedata.com/resource/pubmed/commentcorrection/21150316-16706838, http://linkedlifedata.com/resource/pubmed/commentcorrection/21150316-16809371, http://linkedlifedata.com/resource/pubmed/commentcorrection/21150316-17050707, http://linkedlifedata.com/resource/pubmed/commentcorrection/21150316-17052224, http://linkedlifedata.com/resource/pubmed/commentcorrection/21150316-17514198, http://linkedlifedata.com/resource/pubmed/commentcorrection/21150316-17558391, http://linkedlifedata.com/resource/pubmed/commentcorrection/21150316-17947313, http://linkedlifedata.com/resource/pubmed/commentcorrection/21150316-18256367, http://linkedlifedata.com/resource/pubmed/commentcorrection/21150316-18482979, http://linkedlifedata.com/resource/pubmed/commentcorrection/21150316-18947822, http://linkedlifedata.com/resource/pubmed/commentcorrection/21150316-19710324, http://linkedlifedata.com/resource/pubmed/commentcorrection/21150316-19726659, http://linkedlifedata.com/resource/pubmed/commentcorrection/21150316-20139964, http://linkedlifedata.com/resource/pubmed/commentcorrection/21150316-20363327, http://linkedlifedata.com/resource/pubmed/commentcorrection/21150316-21131953
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1933-6969
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
523-5
pubmed:dateRevised
2011-7-28
pubmed:meshHeading
pubmed:articleTitle
Impact of gating modulation in CaV1.3 L-type calcium channels.
pubmed:affiliation
Pharmacology and Toxicology, Institute of Pharmacy, University of Innsbruck, Innsbruck, Austria. alexandra.koschak@uibk.ac.at
pubmed:publicationType
Journal Article, Review