| pubmed-article:21150113 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21150113 | lifeskim:mentions | umls-concept:C0008802 | lld:lifeskim |
| pubmed-article:21150113 | lifeskim:mentions | umls-concept:C1112857 | lld:lifeskim |
| pubmed-article:21150113 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:21150113 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:21150113 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:21150113 | lifeskim:mentions | umls-concept:C0206131 | lld:lifeskim |
| pubmed-article:21150113 | lifeskim:mentions | umls-concept:C0935929 | lld:lifeskim |
| pubmed-article:21150113 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:21150113 | lifeskim:mentions | umls-concept:C1711411 | lld:lifeskim |
| pubmed-article:21150113 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:21150113 | pubmed:dateCreated | 2010-12-28 | lld:pubmed |
| pubmed-article:21150113 | pubmed:abstractText | It has long been believed that an intake of cinnamon (Cinnamomum zeylanicum) alleviates diabetic pathological conditions. However, it is still controversial whether the beneficial effect is insulin-dependent or insulin-mimetic. This study was aimed at determining the insulin-independent effect of cinnamon. Streptozotocin-induced diabetic rats were divided into four groups and orally administered with an aqueous cinnamon extract (CE) for 22 d. The diabetic rats that had taken CE at a dose of more than 30 mg/kg/d were rescued from their hyperglycemia and nephropathy, and these rats were found to have upregulation of uncoupling protein-1 (UCP-1) and glucose transporter 4 (GLUT4) in their brown adipose tissues as well as in their muscles. This was verified by using 3T3-L1 adipocytes in which CE upregulates GLUT4 translocation and increases the glucose uptake. CE exhibited its anti-diabetic effect independently from insulin by at least two mechanisms: i) upregulation of mitochondrial UCP-1, and ii) enhanced translocation of GLUT4 in the muscle and adipose tissues. | lld:pubmed |
| pubmed-article:21150113 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21150113 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21150113 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21150113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21150113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21150113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21150113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21150113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21150113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21150113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21150113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21150113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21150113 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21150113 | pubmed:issn | 1347-6947 | lld:pubmed |
| pubmed-article:21150113 | pubmed:author | pubmed-author:ShenYanY | lld:pubmed |
| pubmed-article:21150113 | pubmed:author | pubmed-author:SekiTaiichiro... | lld:pubmed |
| pubmed-article:21150113 | pubmed:author | pubmed-author:ArigaToyohiko... | lld:pubmed |
| pubmed-article:21150113 | pubmed:author | pubmed-author:ItoYoshimasaY | lld:pubmed |
| pubmed-article:21150113 | pubmed:author | pubmed-author:HosonoTakashi... | lld:pubmed |
| pubmed-article:21150113 | pubmed:author | pubmed-author:MurakiEtsukoE | lld:pubmed |
| pubmed-article:21150113 | pubmed:author | pubmed-author:FukushimaMisa... | lld:pubmed |
| pubmed-article:21150113 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21150113 | pubmed:volume | 74 | lld:pubmed |
| pubmed-article:21150113 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21150113 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21150113 | pubmed:pagination | 2418-25 | lld:pubmed |
| pubmed-article:21150113 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:21150113 | pubmed:meshHeading | pubmed-meshheading:21150113... | lld:pubmed |
| pubmed-article:21150113 | pubmed:meshHeading | pubmed-meshheading:21150113... | lld:pubmed |
| pubmed-article:21150113 | pubmed:meshHeading | pubmed-meshheading:21150113... | lld:pubmed |
| pubmed-article:21150113 | pubmed:meshHeading | pubmed-meshheading:21150113... | lld:pubmed |
| pubmed-article:21150113 | pubmed:meshHeading | pubmed-meshheading:21150113... | lld:pubmed |
| pubmed-article:21150113 | pubmed:meshHeading | pubmed-meshheading:21150113... | lld:pubmed |
| pubmed-article:21150113 | pubmed:meshHeading | pubmed-meshheading:21150113... | lld:pubmed |
| pubmed-article:21150113 | pubmed:meshHeading | pubmed-meshheading:21150113... | lld:pubmed |
| pubmed-article:21150113 | pubmed:meshHeading | pubmed-meshheading:21150113... | lld:pubmed |
| pubmed-article:21150113 | pubmed:meshHeading | pubmed-meshheading:21150113... | lld:pubmed |
| pubmed-article:21150113 | pubmed:meshHeading | pubmed-meshheading:21150113... | lld:pubmed |
| pubmed-article:21150113 | pubmed:meshHeading | pubmed-meshheading:21150113... | lld:pubmed |
| pubmed-article:21150113 | pubmed:meshHeading | pubmed-meshheading:21150113... | lld:pubmed |
| pubmed-article:21150113 | pubmed:meshHeading | pubmed-meshheading:21150113... | lld:pubmed |
| pubmed-article:21150113 | pubmed:meshHeading | pubmed-meshheading:21150113... | lld:pubmed |
| pubmed-article:21150113 | pubmed:meshHeading | pubmed-meshheading:21150113... | lld:pubmed |
| pubmed-article:21150113 | pubmed:meshHeading | pubmed-meshheading:21150113... | lld:pubmed |
| pubmed-article:21150113 | pubmed:meshHeading | pubmed-meshheading:21150113... | lld:pubmed |
| pubmed-article:21150113 | pubmed:meshHeading | pubmed-meshheading:21150113... | lld:pubmed |
| pubmed-article:21150113 | pubmed:meshHeading | pubmed-meshheading:21150113... | lld:pubmed |
| pubmed-article:21150113 | pubmed:meshHeading | pubmed-meshheading:21150113... | lld:pubmed |
| pubmed-article:21150113 | pubmed:meshHeading | pubmed-meshheading:21150113... | lld:pubmed |
| pubmed-article:21150113 | pubmed:meshHeading | pubmed-meshheading:21150113... | lld:pubmed |
| pubmed-article:21150113 | pubmed:meshHeading | pubmed-meshheading:21150113... | lld:pubmed |
| pubmed-article:21150113 | pubmed:meshHeading | pubmed-meshheading:21150113... | lld:pubmed |
| pubmed-article:21150113 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:21150113 | pubmed:articleTitle | Verification of the antidiabetic effects of cinnamon (Cinnamomum zeylanicum) using insulin-uncontrolled type 1 diabetic rats and cultured adipocytes. | lld:pubmed |
| pubmed-article:21150113 | pubmed:affiliation | Laboratory of Nutrition and Physiology, Department of Chemistry and Life Science, Nihon University College of Bioresource Sciences, Nihon University Graduate School of Bioresource Sciences, Kanagawa, Japan. | lld:pubmed |
| pubmed-article:21150113 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21150113 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
