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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2010-12-28
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pubmed:abstractText |
It has long been believed that an intake of cinnamon (Cinnamomum zeylanicum) alleviates diabetic pathological conditions. However, it is still controversial whether the beneficial effect is insulin-dependent or insulin-mimetic. This study was aimed at determining the insulin-independent effect of cinnamon. Streptozotocin-induced diabetic rats were divided into four groups and orally administered with an aqueous cinnamon extract (CE) for 22 d. The diabetic rats that had taken CE at a dose of more than 30 mg/kg/d were rescued from their hyperglycemia and nephropathy, and these rats were found to have upregulation of uncoupling protein-1 (UCP-1) and glucose transporter 4 (GLUT4) in their brown adipose tissues as well as in their muscles. This was verified by using 3T3-L1 adipocytes in which CE upregulates GLUT4 translocation and increases the glucose uptake. CE exhibited its anti-diabetic effect independently from insulin by at least two mechanisms: i) upregulation of mitochondrial UCP-1, and ii) enhanced translocation of GLUT4 in the muscle and adipose tissues.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1347-6947
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2418-25
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:21150113-3T3-L1 Cells,
pubmed-meshheading:21150113-Adipocytes,
pubmed-meshheading:21150113-Adipocytes, Brown,
pubmed-meshheading:21150113-Animals,
pubmed-meshheading:21150113-Blood Glucose,
pubmed-meshheading:21150113-Body Weight,
pubmed-meshheading:21150113-Cinnamomum zeylanicum,
pubmed-meshheading:21150113-Diabetes Mellitus, Type 1,
pubmed-meshheading:21150113-Fasting,
pubmed-meshheading:21150113-Gene Expression Regulation,
pubmed-meshheading:21150113-Glucose Transporter Type 4,
pubmed-meshheading:21150113-Hypoglycemic Agents,
pubmed-meshheading:21150113-Insulin,
pubmed-meshheading:21150113-Ion Channels,
pubmed-meshheading:21150113-Kidney Glomerulus,
pubmed-meshheading:21150113-Male,
pubmed-meshheading:21150113-Mice,
pubmed-meshheading:21150113-Mitochondrial Proteins,
pubmed-meshheading:21150113-Organ Size,
pubmed-meshheading:21150113-Plant Extracts,
pubmed-meshheading:21150113-Protein Transport,
pubmed-meshheading:21150113-Rats,
pubmed-meshheading:21150113-Rats, Wistar,
pubmed-meshheading:21150113-Reproducibility of Results,
pubmed-meshheading:21150113-Water
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pubmed:year |
2010
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pubmed:articleTitle |
Verification of the antidiabetic effects of cinnamon (Cinnamomum zeylanicum) using insulin-uncontrolled type 1 diabetic rats and cultured adipocytes.
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pubmed:affiliation |
Laboratory of Nutrition and Physiology, Department of Chemistry and Life Science, Nihon University College of Bioresource Sciences, Nihon University Graduate School of Bioresource Sciences, Kanagawa, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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