Switch to
Predicate | Object |
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rdf:type | |
lifeskim:mentions |
umls-concept:C0024880,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0027662,
umls-concept:C0085424,
umls-concept:C0205280,
umls-concept:C0205314,
umls-concept:C0439849,
umls-concept:C0441655,
umls-concept:C0445223,
umls-concept:C0679622,
umls-concept:C1552599,
umls-concept:C1704787,
umls-concept:C1825957
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pubmed:issue |
6
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pubmed:dateCreated |
1990-8-23
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pubmed:abstractText |
We have previously shown that certain bone marrow-derived mast cell (BMMC) lines proliferate in response to a mast cell growth-enhancing activity (MEA) that is distinct from interleukin (IL) 3 and IL 4. Here we provide evidence that MEA is identical with the recently cloned mouse T cell growth factor P40. The evidence is as follows: (a) recombinant P40 displayed all the biological activities ascribed to MEA: it supported the growth of MEA-sensitive BMMC lines, it induced IL 6 secretion by these cells, and it enhanced survival of primary mast cell cultures; (b) highly purified MEA stimulated the growth of P40-dependent cell lines; (c) a rabbit monospecific antiserum directed against P40 specifically inhibited the action of MEA on BMMC; (d) specific binding sites for P40 were detected on BMMC and (e) MEA competed with P40 for binding to P40-dependent T cells, indicating that the two molecules interact with the same receptor. These observations further extend the range of biological activities ascribed to P40 and warrant its proposed designation as IL9.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0014-2980
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1413-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2115002-Animals,
pubmed-meshheading:2115002-Binding, Competitive,
pubmed-meshheading:2115002-Bone Marrow Cells,
pubmed-meshheading:2115002-Growth Substances,
pubmed-meshheading:2115002-Immune Sera,
pubmed-meshheading:2115002-Interleukin-9,
pubmed-meshheading:2115002-Interleukins,
pubmed-meshheading:2115002-Mast Cells,
pubmed-meshheading:2115002-Mice,
pubmed-meshheading:2115002-T-Lymphocytes
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pubmed:year |
1990
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pubmed:articleTitle |
Mast cell growth-enhancing activity (MEA) is structurally related and functionally identical to the novel mouse T cell growth factor P40/TCGFIII (interleukin 9).
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pubmed:affiliation |
GSF-Institut für Experimentelle Hämatologie, Munich, FRG.
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pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro,
Research Support, Non-U.S. Gov't
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