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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2011-1-20
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pubmed:abstractText |
Multiple sites of phosphorylation on human estrogen receptor ? (ER?) have been identified by a variety of methodologies. Now with the emerging availability of phospho-site-specific antibodies to ER?, the relevance of phosphorylation of ER? in human breast cancer in vivo is being explored. Multiple phosphorylated sites in ER? can be detected in multiple breast tumor biopsy samples, providing evidence of their relevance to human breast cancer in vivo. Published data suggest that the detection in primary breast tumors of phosphorylation at some sites in ER? is associated with a better clinical outcome while phosphorylation at other sites is associated with a poorer clinical outcome most often in patients who have been treated with tamoxifen. This suggests the hypothesis that phospho-profiling of ER? in human breast tumors to establish an 'ER? phosphorylation code', may be a more accurate marker of prognosis and/or response to endocrine therapy in human breast cancer.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Hormonal,
http://linkedlifedata.com/resource/pubmed/chemical/Estrogen Receptor alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Estrogens,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proteasome Endopeptidase Complex,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Selective Estrogen Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Tamoxifen,
http://linkedlifedata.com/resource/pubmed/chemical/estrogen receptor alpha, human
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pubmed:status |
MEDLINE
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pubmed:issn |
1479-6821
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
R1-14
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pubmed:meshHeading |
pubmed-meshheading:21149515-Antineoplastic Agents, Hormonal,
pubmed-meshheading:21149515-Biopsy,
pubmed-meshheading:21149515-Breast Neoplasms,
pubmed-meshheading:21149515-Carcinoma,
pubmed-meshheading:21149515-Disease Progression,
pubmed-meshheading:21149515-Drug Resistance, Neoplasm,
pubmed-meshheading:21149515-Estrogen Receptor alpha,
pubmed-meshheading:21149515-Estrogens,
pubmed-meshheading:21149515-Female,
pubmed-meshheading:21149515-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:21149515-Humans,
pubmed-meshheading:21149515-Neoplasm Proteins,
pubmed-meshheading:21149515-Neoplasms, Hormone-Dependent,
pubmed-meshheading:21149515-Phosphorylation,
pubmed-meshheading:21149515-Proteasome Endopeptidase Complex,
pubmed-meshheading:21149515-Protein Kinases,
pubmed-meshheading:21149515-Protein Processing, Post-Translational,
pubmed-meshheading:21149515-Selective Estrogen Receptor Modulators,
pubmed-meshheading:21149515-Signal Transduction,
pubmed-meshheading:21149515-Structure-Activity Relationship,
pubmed-meshheading:21149515-Tamoxifen,
pubmed-meshheading:21149515-Treatment Outcome
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pubmed:year |
2011
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pubmed:articleTitle |
Clinical significance of estrogen receptor phosphorylation.
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pubmed:affiliation |
Department of Biochemistry and Medical Genetics, Faculty of Medicine Manitoba Institute of Cell Biology, University of Manitoba, 675 McDermot Avenue, Winnipeg, Manitoba, Canada. lcmurph@cc.umanitoba.ca
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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