Source:http://linkedlifedata.com/resource/pubmed/id/21148815
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2011-2-11
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| pubmed:abstractText |
E26 Transformation specific (Ets) family transcription factors control the expression of a large number of genes regulating hematopoietic cell development and function. Two such transcription factors, Ets-1 and myeloid Elf-1-like factor (MEF), have been shown to play critical roles in both natural killer (NK)- and NKT-cell development, but not in the development of conventional T cells. In this study, we address the role of E74-like factor 1 (Elf-1), another Ets family transcription factor that is closely related to MEF but divergent from Ets-1, in NK- and NKT-cell development using Elf-1-deficient (Elf-1(-/-)) mice. Whereas the proportion of NK cells in Elf-1(-/-) mice was normal, the proportion of NKT cells was significantly reduced in the thymus and periphery of Elf-1(-/-) mice compared with wild-type (WT) mice. Although Ets-1-deficient mice lack NKT cells altogether, Elf-1(-/-) mice exhibited only a partial block in NKT-cell development caused by a cell-intrinsic defect in the selection, survival, and maturation of NKT cells. In addition, residual NKT cells found in Elf-1(-/-) mice produced less cytokine upon antigen stimulation compared with WT NKT cells. Our data demonstrate that Elf-1 plays an important and nonredundant role in the development and function of NKT cells, but is not involved in NK-cell development.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD1d,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Elf1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Elf4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Ets1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Protein c-ets-1,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
1528-0020
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:day |
10
|
| pubmed:volume |
117
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1880-7
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| pubmed:dateRevised |
2011-6-9
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| pubmed:meshHeading |
pubmed-meshheading:21148815-Animals,
pubmed-meshheading:21148815-Antigen Presentation,
pubmed-meshheading:21148815-Antigens, CD1d,
pubmed-meshheading:21148815-Cell Differentiation,
pubmed-meshheading:21148815-Cell Survival,
pubmed-meshheading:21148815-Cytokines,
pubmed-meshheading:21148815-DNA-Binding Proteins,
pubmed-meshheading:21148815-Genes, T-Cell Receptor alpha,
pubmed-meshheading:21148815-Killer Cells, Natural,
pubmed-meshheading:21148815-Mice,
pubmed-meshheading:21148815-Mice, Congenic,
pubmed-meshheading:21148815-Mice, Inbred C57BL,
pubmed-meshheading:21148815-Mice, Knockout,
pubmed-meshheading:21148815-Natural Killer T-Cells,
pubmed-meshheading:21148815-Nuclear Proteins,
pubmed-meshheading:21148815-Proto-Oncogene Protein c-ets-1,
pubmed-meshheading:21148815-Transcription Factors,
pubmed-meshheading:21148815-Transplantation Chimera
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| pubmed:year |
2011
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| pubmed:articleTitle |
Differential requirements for the Ets transcription factor Elf-1 in the development of NKT cells and NK cells.
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| pubmed:affiliation |
Department of Microbiology and Immunology, Northwestern University, Chicago, IL 60611, USA.
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| pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, N.I.H., Extramural
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