| pubmed-article:21148572 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21148572 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:21148572 | lifeskim:mentions | umls-concept:C1332743 | lld:lifeskim |
| pubmed-article:21148572 | lifeskim:mentions | umls-concept:C0038351 | lld:lifeskim |
| pubmed-article:21148572 | lifeskim:mentions | umls-concept:C0031437 | lld:lifeskim |
| pubmed-article:21148572 | lifeskim:mentions | umls-concept:C0019868 | lld:lifeskim |
| pubmed-article:21148572 | lifeskim:mentions | umls-concept:C0334037 | lld:lifeskim |
| pubmed-article:21148572 | lifeskim:mentions | umls-concept:C0205360 | lld:lifeskim |
| pubmed-article:21148572 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:21148572 | pubmed:dateCreated | 2011-2-7 | lld:pubmed |
| pubmed-article:21148572 | pubmed:abstractText | Intestinal metaplasia (IM) is a gastric preneoplastic lesion that appears following Helicobacter pylori infection and confers an increased risk for development of cancer. It is induced by gastric expression of the intestine-specific transcription factor CDX2. The regulatory mechanisms involved in triggering and maintaining gastric CDX2 expression have not been fully elucidated. The Cdx2(+/-) mouse develops intestinal polyps with gastric differentiation and total loss of Cdx2 expression in the absence of structural loss of the second allele, suggesting a regulatory defect. This putative haplo-insufficiency, together with the apparent stability of IM, led to the hypothesis that CDX2 regulates its own expression through an autoregulatory loop in both contexts. | lld:pubmed |
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| pubmed-article:21148572 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21148572 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21148572 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:21148572 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21148572 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:21148572 | pubmed:issn | 1468-3288 | lld:pubmed |
| pubmed-article:21148572 | pubmed:author | pubmed-author:FreundJean-No... | lld:pubmed |
| pubmed-article:21148572 | pubmed:author | pubmed-author:Pinto-de-Sous... | lld:pubmed |
| pubmed-article:21148572 | pubmed:author | pubmed-author:DavidLeonorL | lld:pubmed |
| pubmed-article:21148572 | pubmed:author | pubmed-author:DulucIsabelle... | lld:pubmed |
| pubmed-article:21148572 | pubmed:author | pubmed-author:AlmeidaRaquel... | lld:pubmed |
| pubmed-article:21148572 | pubmed:author | pubmed-author:BarrosRitaR | lld:pubmed |
| pubmed-article:21148572 | pubmed:author | pubmed-author:da... | lld:pubmed |
| pubmed-article:21148572 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21148572 | pubmed:volume | 60 | lld:pubmed |
| pubmed-article:21148572 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21148572 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21148572 | pubmed:pagination | 290-8 | lld:pubmed |
| pubmed-article:21148572 | pubmed:dateRevised | 2011-7-25 | lld:pubmed |
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| pubmed-article:21148572 | pubmed:meshHeading | pubmed-meshheading:21148572... | lld:pubmed |
| pubmed-article:21148572 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21148572 | pubmed:articleTitle | CDX2 autoregulation in human intestinal metaplasia of the stomach: impact on the stability of the phenotype. | lld:pubmed |
| pubmed-article:21148572 | pubmed:affiliation | IPATIMUP, Rua Dr Roberto Frias s/n, 4200-465 Porto, Portugal. | lld:pubmed |
| pubmed-article:21148572 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21148572 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
