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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2011-2-7
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pubmed:abstractText |
Intestinal metaplasia (IM) is a gastric preneoplastic lesion that appears following Helicobacter pylori infection and confers an increased risk for development of cancer. It is induced by gastric expression of the intestine-specific transcription factor CDX2. The regulatory mechanisms involved in triggering and maintaining gastric CDX2 expression have not been fully elucidated. The Cdx2(+/-) mouse develops intestinal polyps with gastric differentiation and total loss of Cdx2 expression in the absence of structural loss of the second allele, suggesting a regulatory defect. This putative haplo-insufficiency, together with the apparent stability of IM, led to the hypothesis that CDX2 regulates its own expression through an autoregulatory loop in both contexts.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1468-3288
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
290-8
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pubmed:dateRevised |
2011-7-25
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pubmed:meshHeading |
pubmed-meshheading:21148572-Adenocarcinoma,
pubmed-meshheading:21148572-Animals,
pubmed-meshheading:21148572-Gene Expression Regulation,
pubmed-meshheading:21148572-Homeodomain Proteins,
pubmed-meshheading:21148572-Homeostasis,
pubmed-meshheading:21148572-Humans,
pubmed-meshheading:21148572-Ileum,
pubmed-meshheading:21148572-Metaplasia,
pubmed-meshheading:21148572-Mice,
pubmed-meshheading:21148572-Neoplasm Proteins,
pubmed-meshheading:21148572-Point Mutation,
pubmed-meshheading:21148572-Precancerous Conditions,
pubmed-meshheading:21148572-Promoter Regions, Genetic,
pubmed-meshheading:21148572-Stomach,
pubmed-meshheading:21148572-Stomach Neoplasms,
pubmed-meshheading:21148572-Transfection,
pubmed-meshheading:21148572-Tumor Cells, Cultured
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pubmed:year |
2011
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pubmed:articleTitle |
CDX2 autoregulation in human intestinal metaplasia of the stomach: impact on the stability of the phenotype.
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pubmed:affiliation |
IPATIMUP, Rua Dr Roberto Frias s/n, 4200-465 Porto, Portugal.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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