Linked Life Data

21147639

Source:http://linkedlifedata.com/resource/pubmed/id/21147639

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2010-12-14
pubmed:abstractText
Obesity is a multifactor disease with a very complicated etiology. Genetic factors play an important role in the development of primary obesity. They may be responsible for up to 40% of causes leading to obesity. There are a great number of genes affecting food intake and energy expenditure. Serious consequences accompanying obesity, e.g., type 2 diabetes and lipid abnormalities may be caused by increased level of proinflammatory cytokines, such as IL-1, IL-6, and TNF. It is possible that polymorphisms located in cytokine genes affect the level of protein expression. It is known that IL-6 plays a role in lipid metabolism and energy expenditure. The polymorphism found in point 174 (G174C) of a promoter region of IL-6 gene affects the level of interleukin-6 expression and, consequently, may lead to obesity and correlated conditions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0949-2321
pubmed:author
pubmed:issnType
Print
pubmed:day
4
pubmed:volume
15 Suppl 2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
123-7
pubmed:dateRevised
2011-3-21
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Influence of interleukin-6 and G174C polymorphism in IL-6 gene on obesity and energy balance.
pubmed:affiliation
Department of Laboratory Diagnostics, Warsaw Medical University, Warsaw, Poland. aksiak@interia.pl
pubmed:publicationType
Journal Article, Review