| pubmed-article:21147078 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21147078 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:21147078 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:21147078 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:21147078 | lifeskim:mentions | umls-concept:C0349543 | lld:lifeskim |
| pubmed-article:21147078 | lifeskim:mentions | umls-concept:C0596290 | lld:lifeskim |
| pubmed-article:21147078 | lifeskim:mentions | umls-concept:C0521451 | lld:lifeskim |
| pubmed-article:21147078 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:21147078 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:21147078 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:21147078 | lifeskim:mentions | umls-concept:C1567863 | lld:lifeskim |
| pubmed-article:21147078 | pubmed:dateCreated | 2011-1-24 | lld:pubmed |
| pubmed-article:21147078 | pubmed:abstractText | Novaeguinoside II is one of the newly found asterosaponins, which are a kind of steroidal glycosides extracted from starfish with an anti-tumor effect. In this study, we investigated the bioactivity of novaeguinoside II on human U87MG glioblastoma cells. The results showed that novaeguinoside II significantly suppresses U87MG cell proliferation in a time- and concentration-dependent manner. Flow cytometric analysis of DNA in U87MG cells showed that novaeguinoside II induces the prominent appearance of an S phase peak in the cell cycle that is suggestive of apoptosis that is identical to the result of an annexin V/PI assay. Fluorescence and electron microscopy revealed apoptotic change of U87MG cells. The electrophoresis of DNA showed a typical "ladder" that is consistent with apoptotic DNA fragmentation. Cytofluorometry showed a decreased mitochondrial transmembrane potential in novaeguinoside II-treated U87MG cells. Western blot showed that novaeguinoside II increased the expression of cytochrome-c and caspase-3 protein. The novel findings suggest that novaeguinoside II can induce apoptosis of U87MG cells by a mitochondrial apoptotic pathway. | lld:pubmed |
| pubmed-article:21147078 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21147078 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21147078 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21147078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21147078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21147078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21147078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21147078 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21147078 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:21147078 | pubmed:issn | 1872-6240 | lld:pubmed |
| pubmed-article:21147078 | pubmed:author | pubmed-author:ZhouJieJ | lld:pubmed |
| pubmed-article:21147078 | pubmed:author | pubmed-author:ChengGangG | lld:pubmed |
| pubmed-article:21147078 | pubmed:author | pubmed-author:ZhangXiangX | lld:pubmed |
| pubmed-article:21147078 | pubmed:author | pubmed-author:TangHai-FengH... | lld:pubmed |
| pubmed-article:21147078 | pubmed:author | pubmed-author:ChengGuangG | lld:pubmed |
| pubmed-article:21147078 | pubmed:copyrightInfo | Copyright © 2010 Elsevier B.V. All rights reserved. | lld:pubmed |
| pubmed-article:21147078 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21147078 | pubmed:day | 4 | lld:pubmed |
| pubmed-article:21147078 | pubmed:volume | 1372 | lld:pubmed |
| pubmed-article:21147078 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21147078 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21147078 | pubmed:pagination | 22-8 | lld:pubmed |
| pubmed-article:21147078 | pubmed:meshHeading | pubmed-meshheading:21147078... | lld:pubmed |
| pubmed-article:21147078 | pubmed:meshHeading | pubmed-meshheading:21147078... | lld:pubmed |
| pubmed-article:21147078 | pubmed:meshHeading | pubmed-meshheading:21147078... | lld:pubmed |
| pubmed-article:21147078 | pubmed:meshHeading | pubmed-meshheading:21147078... | lld:pubmed |
| pubmed-article:21147078 | pubmed:meshHeading | pubmed-meshheading:21147078... | lld:pubmed |
| pubmed-article:21147078 | pubmed:meshHeading | pubmed-meshheading:21147078... | lld:pubmed |
| pubmed-article:21147078 | pubmed:meshHeading | pubmed-meshheading:21147078... | lld:pubmed |
| pubmed-article:21147078 | pubmed:meshHeading | pubmed-meshheading:21147078... | lld:pubmed |
| pubmed-article:21147078 | pubmed:meshHeading | pubmed-meshheading:21147078... | lld:pubmed |
| pubmed-article:21147078 | pubmed:meshHeading | pubmed-meshheading:21147078... | lld:pubmed |
| pubmed-article:21147078 | pubmed:meshHeading | pubmed-meshheading:21147078... | lld:pubmed |
| pubmed-article:21147078 | pubmed:meshHeading | pubmed-meshheading:21147078... | lld:pubmed |
| pubmed-article:21147078 | pubmed:meshHeading | pubmed-meshheading:21147078... | lld:pubmed |
| pubmed-article:21147078 | pubmed:meshHeading | pubmed-meshheading:21147078... | lld:pubmed |
| pubmed-article:21147078 | pubmed:meshHeading | pubmed-meshheading:21147078... | lld:pubmed |
| pubmed-article:21147078 | pubmed:meshHeading | pubmed-meshheading:21147078... | lld:pubmed |
| pubmed-article:21147078 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21147078 | pubmed:articleTitle | Novaeguinoside II inhibits cell proliferation and induces apoptosis of human brain glioblastoma U87MG cells through the mitochondrial pathway. | lld:pubmed |
| pubmed-article:21147078 | pubmed:affiliation | Institute of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, People's Republic of China. | lld:pubmed |
| pubmed-article:21147078 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21147078 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
