Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2011-1-25
pubmed:abstractText
The penetration of acetylcholinesterase reactivators (oximes) into the central nervous system is typically restricted by the blood-brain barrier. Although oximes are highly hydrophilic compounds, some contradictory results confirming permeation into the brain exist. The aim of this study is to verify the penetration of oximes through the blood-brain barrier and to detect their levels achieved in different brain regions 60 min after the administration. It was confirmed that oximes are able to penetrate into the brain after injection of therapeutic doses corresponding with 5% of LD(50). The level in whole brain was 0.58% for trimedoxime and 0.85% for the experimental drug oxime K074 as the percentage of their plasma concentration. The highest concentration was found in frontal cortex (trimedoxime 2.27%; oxime K074 0.95%) and lowest in basal ganglia (trimedoxime 0.86%; oxime K074 0.42%). Entry of oximes into the brain is minimal, but some low reactivation effect should be expected. The reactivation potency of oximes might be higher or lower, depending on the real oxime concentration in a given area.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1873-264X
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier B.V. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
5
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1082-7
pubmed:meshHeading
pubmed-meshheading:21146949-Animals, pubmed-meshheading:21146949-Brain, pubmed-meshheading:21146949-Butanes, pubmed-meshheading:21146949-Calibration, pubmed-meshheading:21146949-Cholinesterase Reactivators, pubmed-meshheading:21146949-Chromatography, High Pressure Liquid, pubmed-meshheading:21146949-Injections, Intramuscular, pubmed-meshheading:21146949-Limit of Detection, pubmed-meshheading:21146949-Male, pubmed-meshheading:21146949-Molecular Structure, pubmed-meshheading:21146949-Oximes, pubmed-meshheading:21146949-Pyridinium Compounds, pubmed-meshheading:21146949-Rats, pubmed-meshheading:21146949-Rats, Wistar, pubmed-meshheading:21146949-Reference Standards, pubmed-meshheading:21146949-Regression Analysis, pubmed-meshheading:21146949-Reproducibility of Results, pubmed-meshheading:21146949-Tissue Distribution, pubmed-meshheading:21146949-Trimedoxime
pubmed:year
2011
pubmed:articleTitle
Partition of bispyridinium oximes (trimedoxime and K074) administered in therapeutic doses into different parts of the rat brain.
pubmed:affiliation
Department of Public Health, Faculty of Military Health Sciences, Trebesska 1575, Hradec Kralove, Czech Republic. karasova@pmfhk.cz
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't