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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2011-6-13
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pubmed:abstractText |
Bleeding in acute promyelocytic leukemia (APL) is mainly associated with disseminated intravascular coagulation and hyperfibrinolysis. Annexin II (Ann II) is a co-receptor for plasminogen and tissue plasminogen activator (tPA). This study demonstrates that abnormally high levels of Ann II expression in APL cells increase the production of plasmin. Hyperfibrinolysis could be corrected by all-trans retinoic acid (ATRA) or ATRA plus arsenic trioxide therapy in patients with APL. SiRNA targetting Ann II caused a decrease in tPA-dependent plasmin generation, while Ann II cDNA transfectant stimulated plasmin production. These results suggest that Ann II play an important role in hyperfibrinolysis in APL.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Annexin A2,
http://linkedlifedata.com/resource/pubmed/chemical/Arsenicals,
http://linkedlifedata.com/resource/pubmed/chemical/Fibrinolysin,
http://linkedlifedata.com/resource/pubmed/chemical/Oxides,
http://linkedlifedata.com/resource/pubmed/chemical/Plasminogen,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/Tissue Plasminogen Activator,
http://linkedlifedata.com/resource/pubmed/chemical/Tretinoin,
http://linkedlifedata.com/resource/pubmed/chemical/arsenic trioxide
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1873-5835
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
879-84
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pubmed:meshHeading |
pubmed-meshheading:21146216-Adolescent,
pubmed-meshheading:21146216-Adult,
pubmed-meshheading:21146216-Aged,
pubmed-meshheading:21146216-Annexin A2,
pubmed-meshheading:21146216-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:21146216-Arsenicals,
pubmed-meshheading:21146216-Blood Coagulation Tests,
pubmed-meshheading:21146216-Blotting, Western,
pubmed-meshheading:21146216-Cell Proliferation,
pubmed-meshheading:21146216-Female,
pubmed-meshheading:21146216-Fibrinolysin,
pubmed-meshheading:21146216-Fibrinolysis,
pubmed-meshheading:21146216-Flow Cytometry,
pubmed-meshheading:21146216-Humans,
pubmed-meshheading:21146216-Leukemia, Promyelocytic, Acute,
pubmed-meshheading:21146216-Male,
pubmed-meshheading:21146216-Middle Aged,
pubmed-meshheading:21146216-Oxides,
pubmed-meshheading:21146216-Plasminogen,
pubmed-meshheading:21146216-RNA, Messenger,
pubmed-meshheading:21146216-RNA, Small Interfering,
pubmed-meshheading:21146216-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:21146216-Tissue Plasminogen Activator,
pubmed-meshheading:21146216-Tretinoin,
pubmed-meshheading:21146216-Young Adult
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pubmed:year |
2011
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pubmed:articleTitle |
The expression of annexin II and its role in the fibrinolytic activity in acute promyelocytic leukemia.
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pubmed:affiliation |
Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, 188 Shizi Street, Suzhou, Jiangsu Province 215006, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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