rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2011-5-20
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pubmed:abstractText |
Several lines of evidence suggest that innate immunity plays a key role in hepatic fibrogenesis. To clarify the role of natural killer (NK) T cells in hepatic inflammation and fibrogenesis, we here investigated xenobiotics-induced liver injury and subsequent fibrogenesis in mice lacking mature NKT cells caused by genetic disruption of the CD1d molecule.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD1d,
http://linkedlifedata.com/resource/pubmed/chemical/Cd1d1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen Type I,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Thioacetamide,
http://linkedlifedata.com/resource/pubmed/chemical/Tissue Inhibitor of...,
http://linkedlifedata.com/resource/pubmed/chemical/collagen type I, alpha 1 chain
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0168-8278
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pubmed:author |
|
pubmed:copyrightInfo |
Copyright © 2010 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
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pubmed:issnType |
Print
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1195-204
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pubmed:meshHeading |
pubmed-meshheading:21145835-Animals,
pubmed-meshheading:21145835-Antigens, CD1d,
pubmed-meshheading:21145835-Base Sequence,
pubmed-meshheading:21145835-Cell Death,
pubmed-meshheading:21145835-Collagen Type I,
pubmed-meshheading:21145835-Drug-Induced Liver Injury,
pubmed-meshheading:21145835-Hepatocytes,
pubmed-meshheading:21145835-Immunity, Innate,
pubmed-meshheading:21145835-Liver Cirrhosis,
pubmed-meshheading:21145835-Male,
pubmed-meshheading:21145835-Mice,
pubmed-meshheading:21145835-Mice, Inbred C57BL,
pubmed-meshheading:21145835-Mice, Knockout,
pubmed-meshheading:21145835-Natural Killer T-Cells,
pubmed-meshheading:21145835-RNA, Messenger,
pubmed-meshheading:21145835-Thioacetamide,
pubmed-meshheading:21145835-Tissue Inhibitor of Metalloproteinase-1
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pubmed:year |
2011
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pubmed:articleTitle |
CD1d-restricted natural killer T cells contribute to hepatic inflammation and fibrogenesis in mice.
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pubmed:affiliation |
Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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