|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0012854,
umls-concept:C0021760,
umls-concept:C0044602,
umls-concept:C0164786,
umls-concept:C0227525,
umls-concept:C0285761,
umls-concept:C0443264,
umls-concept:C0812228,
umls-concept:C0871261,
umls-concept:C1150481,
umls-concept:C1368105,
umls-concept:C1451005,
umls-concept:C1704632,
umls-concept:C1705325,
umls-concept:C1706817,
umls-concept:C1879547,
umls-concept:C1883254,
umls-concept:C2911692
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2011-4-18
|
|
pubmed:abstractText |
Interleukin-6 (IL-6) is a crucial factor in liver regeneration following partial hepatectomy (PH); however, the role of IL-6 and IL-6 trans-signaling in particular, in hepatocyte mitosis remains controversial. IL-6 trans-signaling relies upon the release of the soluble IL-6R (sIL-6R), which binds IL-6 to form an agonistic IL-6/sIL-6R complex. Herein we have examined the hypothesis that IL-6 trans-signaling plays a crucial and distinct role in liver regeneration following PH.
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|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0168-8278
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
Copyright © 2010 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
54
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
922-9
|
|
pubmed:meshHeading |
pubmed-meshheading:21145830-Animals,
pubmed-meshheading:21145830-Gene Expression,
pubmed-meshheading:21145830-Hepatectomy,
pubmed-meshheading:21145830-Hepatocytes,
pubmed-meshheading:21145830-Interleukin-6,
pubmed-meshheading:21145830-Liver Regeneration,
pubmed-meshheading:21145830-Male,
pubmed-meshheading:21145830-Mice,
pubmed-meshheading:21145830-Mice, Inbred BALB C,
pubmed-meshheading:21145830-Mice, Inbred C57BL,
pubmed-meshheading:21145830-Mitogen-Activated Protein Kinases,
pubmed-meshheading:21145830-Mitosis,
pubmed-meshheading:21145830-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:21145830-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:21145830-Receptors, Interleukin-6,
pubmed-meshheading:21145830-STAT3 Transcription Factor,
pubmed-meshheading:21145830-Signal Transduction,
pubmed-meshheading:21145830-Transfection
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|
pubmed:year |
2011
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|
pubmed:articleTitle |
Early hepatocyte DNA synthetic response posthepatectomy is modulated by IL-6 trans-signaling and PI3K/AKT activation.
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|
pubmed:affiliation |
The Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem, Israel.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
