Linked Life Data

21145564

Source:http://linkedlifedata.com/resource/pubmed/id/21145564

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2011-4-11
pubmed:abstractText
Bovine spongiform encephalopathy (BSE) is a prion disease of domesticated cattle, first identified in Great Britain (GB) in 1986. The disease has been characterized by histopathological, immunohistochemical, biochemical and biological properties, which have shown a consistent disease phenotype among cases obtained by passive surveillance. With the advent of active surveillance in 2001, immunological tests for detection of the prion protein revealed some cases with different biochemical characteristics and, in certain instances, differences in pathology that have indicated variant phenotypes and the possibility of agent strain variation. This study examines a case set of 523 bovine brains derived from archived material identified through passive surveillance in GB. All cases conformed to the phenotype of classical BSE (BSE-C) by histopathological, immunohistochemical and biochemical approaches. The analyses consolidated an understanding of BSE-C and, by western blotting, confirmed differentiation from the known atypical BSE cases which exhibit higher or lower molecular masses than BSE-C (BSE-H and BSE-L respectively).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1532-3129
pubmed:author
pubmed:copyrightInfo
Crown Copyright © 2010. Published by Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
144
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
277-88
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Bovine spongiform encephalopathy: investigation of phenotypic variation among passive surveillance cases.
pubmed:affiliation
Veterinary Laboratories Agency, Woodham Lane, Addlestone, Surrey KT153NB, UK. furuoka@obihiro.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't