| pubmed-article:21145286 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21145286 | lifeskim:mentions | umls-concept:C1384666 | lld:lifeskim |
| pubmed-article:21145286 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:21145286 | lifeskim:mentions | umls-concept:C0041348 | lld:lifeskim |
| pubmed-article:21145286 | lifeskim:mentions | umls-concept:C0443146 | lld:lifeskim |
| pubmed-article:21145286 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:21145286 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:21145286 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:21145286 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:21145286 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:21145286 | pubmed:dateCreated | 2011-2-1 | lld:pubmed |
| pubmed-article:21145286 | pubmed:abstractText | Autoimmune inner ear disease is described as progressive, bilateral although asymmetric, sensorineural hearing loss and can be improved by immunosuppressive therapy. We showed that the inner ear autoantigen ?-tubulin is capable of inducing experimental autoimmune hearing loss (EAHL) in mice. Immunization of BALB/c mice with ?-tubulin resulted in hair cell loss and hearing loss, effects that were not seen in animals immunized with control peptide. Moreover, the EAHL model showed that ?-tubulin responsiveness involved CD4(+) T cells producing IFN-?, and T cell mediation of EAHL was determined by significantly increased auditory brainstem response after adoptive transfer of ?-tubulin-activated CD4(+) T cells into naive BALB/c recipients. The potential mechanisms responsible for the observed pathology of EAHL can be attributed to decreased frequency and impaired suppressive function of regulatory T cells. Our study suggests that EAHL may be a T cell-mediated organ-specific autoimmune disorder of the inner ear. | lld:pubmed |
| pubmed-article:21145286 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21145286 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21145286 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21145286 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21145286 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21145286 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21145286 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21145286 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21145286 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:21145286 | pubmed:issn | 1521-7035 | lld:pubmed |
| pubmed-article:21145286 | pubmed:author | pubmed-author:ZhouBinB | lld:pubmed |
| pubmed-article:21145286 | pubmed:author | pubmed-author:CaiQingQ | lld:pubmed |
| pubmed-article:21145286 | pubmed:author | pubmed-author:NairUshaU | lld:pubmed |
| pubmed-article:21145286 | pubmed:author | pubmed-author:CaiChunC | lld:pubmed |
| pubmed-article:21145286 | pubmed:author | pubmed-author:LiuWenxiaW | lld:pubmed |
| pubmed-article:21145286 | pubmed:author | pubmed-author:KanangatSivaS | lld:pubmed |
| pubmed-article:21145286 | pubmed:author | pubmed-author:KimJun WooJW | lld:pubmed |
| pubmed-article:21145286 | pubmed:author | pubmed-author:KermanyMohamm... | lld:pubmed |
| pubmed-article:21145286 | pubmed:author | pubmed-author:KimPatrickP | lld:pubmed |
| pubmed-article:21145286 | pubmed:author | pubmed-author:YooTai JuneTJ | lld:pubmed |
| pubmed-article:21145286 | pubmed:author | pubmed-author:GlicksteinJon... | lld:pubmed |
| pubmed-article:21145286 | pubmed:author | pubmed-author:ZhouYixuanY | lld:pubmed |
| pubmed-article:21145286 | pubmed:copyrightInfo | Published by Elsevier Inc. | lld:pubmed |
| pubmed-article:21145286 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21145286 | pubmed:volume | 138 | lld:pubmed |
| pubmed-article:21145286 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21145286 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21145286 | pubmed:pagination | 222-30 | lld:pubmed |
| pubmed-article:21145286 | pubmed:meshHeading | pubmed-meshheading:21145286... | lld:pubmed |
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| pubmed-article:21145286 | pubmed:meshHeading | pubmed-meshheading:21145286... | lld:pubmed |
| pubmed-article:21145286 | pubmed:meshHeading | pubmed-meshheading:21145286... | lld:pubmed |
| pubmed-article:21145286 | pubmed:meshHeading | pubmed-meshheading:21145286... | lld:pubmed |
| pubmed-article:21145286 | pubmed:meshHeading | pubmed-meshheading:21145286... | lld:pubmed |
| pubmed-article:21145286 | pubmed:meshHeading | pubmed-meshheading:21145286... | lld:pubmed |
| pubmed-article:21145286 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21145286 | pubmed:articleTitle | Murine autoimmune hearing loss mediated by CD4+ T cells specific for ?-tubulin. | lld:pubmed |
| pubmed-article:21145286 | pubmed:affiliation | Department of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA. | lld:pubmed |
| pubmed-article:21145286 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21145286 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
