Linked Life Data

21145286

Source:http://linkedlifedata.com/resource/pubmed/id/21145286

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-2-1
pubmed:abstractText
Autoimmune inner ear disease is described as progressive, bilateral although asymmetric, sensorineural hearing loss and can be improved by immunosuppressive therapy. We showed that the inner ear autoantigen ?-tubulin is capable of inducing experimental autoimmune hearing loss (EAHL) in mice. Immunization of BALB/c mice with ?-tubulin resulted in hair cell loss and hearing loss, effects that were not seen in animals immunized with control peptide. Moreover, the EAHL model showed that ?-tubulin responsiveness involved CD4(+) T cells producing IFN-?, and T cell mediation of EAHL was determined by significantly increased auditory brainstem response after adoptive transfer of ?-tubulin-activated CD4(+) T cells into naive BALB/c recipients. The potential mechanisms responsible for the observed pathology of EAHL can be attributed to decreased frequency and impaired suppressive function of regulatory T cells. Our study suggests that EAHL may be a T cell-mediated organ-specific autoimmune disorder of the inner ear.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1521-7035
pubmed:author
pubmed:copyrightInfo
Published by Elsevier Inc.
pubmed:issnType
Electronic
pubmed:volume
138
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
222-30
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Murine autoimmune hearing loss mediated by CD4+ T cells specific for ?-tubulin.
pubmed:affiliation
Department of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural