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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-12-24
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pubmed:abstractText |
Prolactin is a polypeptide hormone responsible for proliferation and differentiation of the mammary gland. More recently, prolactin's role in mammary carcinogenesis has been studied with greater interest. Studies from our laboratory and from others have demonstrated that three specific isoforms of the prolactin receptor (PRLR) are expressed in both normal and cancerous breast cells and tissues. Until now, reliable isoform specific antibodies have been lacking. We have prepared and characterized polyclonal antibodies against each of the human PRLR isoforms that can effectively be used to characterize human breast cancers.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2407
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
678
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pubmed:meshHeading |
pubmed-meshheading:21144038-Animals,
pubmed-meshheading:21144038-Antibodies,
pubmed-meshheading:21144038-Antibody Specificity,
pubmed-meshheading:21144038-Biopsy,
pubmed-meshheading:21144038-Blotting, Western,
pubmed-meshheading:21144038-Breast Neoplasms,
pubmed-meshheading:21144038-CHO Cells,
pubmed-meshheading:21144038-Carcinoma, Ductal, Breast,
pubmed-meshheading:21144038-Carcinoma, Lobular,
pubmed-meshheading:21144038-Cell Line, Tumor,
pubmed-meshheading:21144038-Cricetinae,
pubmed-meshheading:21144038-Cricetulus,
pubmed-meshheading:21144038-Female,
pubmed-meshheading:21144038-Humans,
pubmed-meshheading:21144038-Immunohistochemistry,
pubmed-meshheading:21144038-Mice,
pubmed-meshheading:21144038-Mice, Nude,
pubmed-meshheading:21144038-Protein Isoforms,
pubmed-meshheading:21144038-RNA, Messenger,
pubmed-meshheading:21144038-Rabbits,
pubmed-meshheading:21144038-Receptors, Prolactin,
pubmed-meshheading:21144038-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:21144038-Transfection
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pubmed:year |
2010
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pubmed:articleTitle |
Characterization of ductal and lobular breast carcinomas using novel prolactin receptor isoform specific antibodies.
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pubmed:affiliation |
Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. eg20e@nih.gov
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Intramural
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