One of the most distinctive features of ankylosing spondylitis (AS) is new bone formation and bone resorption at sites of chronic inflammation. Previous studies have indicated that the hyperplasia and inflammation of synovial tissues are significantly related to the pathogenic process of AS. The present study used a proteomic approach to identify novel AS-specific proteins by simultaneously comparing the expression profiles of synovial membranes from patients with AS, rheumatoid arthritis (RA) and osteoarthritis (OA).
National Laboratory for Bio-Drugs of Ministry of Health, Research Center for Medicinal Biotechnology of Shandong Academy of Medical Sciences, Jingshi road 18877, Jinan, Shandong, 250062, PR China. changxt@126.com
