Linked Life Data

21143776

Source:http://linkedlifedata.com/resource/pubmed/id/21143776

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2010-12-14
pubmed:abstractText
Effector secretion is a common strategy of pathogen in mediating host-pathogen interaction. Eight EPIYA-motif containing effectors have recently been discovered in six pathogens. Once these effectors enter host cells through type III/IV secretion systems (T3SS/T4SS), tyrosine in the EPIYA motif is phosphorylated, which triggers effectors binding other proteins to manipulate host-cell functions. The objectives of this study are to evaluate the distribution pattern of EPIYA motif in broad biological species, to predict potential effectors with EPIYA motif, and to suggest roles and biological functions of potential effectors in host-pathogen interactions.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1471-2164
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
11 Suppl 3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S1
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Effector prediction in host-pathogen interaction based on a Markov model of a ubiquitous EPIYA motif.
pubmed:affiliation
Department of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu 210029, China. xushfu@njmu.edu.cn
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural