Linked Life Data

21141674

Source:http://linkedlifedata.com/resource/pubmed/id/21141674

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2010-12-14
pubmed:abstractText
This work presents an overview of the use of liposomes for targeted delivery of photosensitizers to tumors for Photodynamic Therapy (PDT). It assesses the results of a quantitative model to explain the interaction of short-pulsed lasers (in the nanosecond and picosecond domains) with a liposome-dye complex in terms of a localized photo-induced thermal mechanism. Incorporation of an organic dye (sulforhodamine) within lipid vesicles has been investigated in conjunction with the effect of laser irradiation on the integrity of the liposome-dye complex. The variation of the absorption coefficient as a function of wavelength for dye-encapsulated liposomes before and after laser-induced release of dye was studied and modeled. The commercial software Mathematica was used to develop a Gaussian model for the energy absorption by the liposome-dye complex. Dye release from 3 microm - liposome encapsulating 25 mM aqueous solution of sulforhodamine dye was studied using 8 ns laser pulses at the second harmonic of the Nd:YAG laser (at 532 nm) and compared with dye release employing 25 ps - laser pulses. In addition, the temperature-dependence of the dye release has been included in the photo-thermal model.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1556-5297
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
203-12
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Simulation and modeling of laser-tissue interactions based on a liposome-dye system.
pubmed:affiliation
University of the District of Columbia, Washington, DC, USA.
pubmed:publicationType
Journal Article