Linked Life Data

21139418

Source:http://linkedlifedata.com/resource/pubmed/id/21139418

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2010-12-8
pubmed:abstractText
Stargazin, a transmembrane protein expressed in the nervous system, shares similarities with the ?? subunit of skeletal muscle calcium channels. It was thus termed ?? subunit of neuronal calcium channels. Stargazin downregulates the expression of Ca(V)2 channels, however, its functional modulation of these channels remains debated. We have reported that Stargazin modulates Ca(V)2.2 channel by a G??-dependent mechanism and suggested that Stargazin is not a true subunit of this channel, since all its effects on channel function are dependent on the presence of G??. Moreover, Stargazin also modulated the GIRK channel in a G??-dependent fashion. Here we report that G??-dependent modulation by Stargazin of the biophysical properties of Ca(V)2.2 is unrelated to its negative effect on channel expression and current amplitude. Finally, we suggest that this G?? dependent modulation of Stargazin may have physiological relevance, since it was still present when we used Ca²(+) as charge carrier, instead of Ba²(+).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1933-6969
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
351-4
pubmed:meshHeading
pubmed:articleTitle
Further characterization of regulation of Ca(V)2.2 by stargazin.
pubmed:affiliation
Department of Physiology and Pharmacology, Tel Aviv University, Israel. isabell1@post.tau.ac.il
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't