Linked Life Data

21139376

Source:http://linkedlifedata.com/resource/pubmed/id/21139376

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2010-12-8
pubmed:abstractText
The biologically active form of vitamin D, 1?,25-dihydroxy vitamin D? (VD), regulates the synthesis of the bone Ca-binding proteins osteocalcin and osteopontin. The actions of VD are mediated through the vitamin D receptor (VDR). Liganded VDR heterodimerizes with the retinoid X receptor and interacts with a vitamin D response element (VDRE). Recently, it has been demonstrated that vitamin D responses elicited in osteoblasts can be rapid as well as long-term. The purpose of this study was to elucidate the mechanism of Ca(2+) signaling of VD in osteoblasts using intracellular Ca(2+) ([Ca(2+)]i) measurements. A rapid VD (10 nM)-induced increase in [Ca(2+)]i was observed within 40 sec. This increase, however, was negated with application of Ca(2+)-free Krebs' solution. These results indicate that VD induces an increase in [Ca(2+)]i from extracellular Ca(2+) in osteoblasts.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0040-8891
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
221-6
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
1?,25-dihydroxyvitamin D? rapidly modulates Ca(2+) influx in osteoblasts mediated by Ca(2+) channels.
pubmed:affiliation
Department of Orthodontics, Tokyo Dental College, Chiba, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't