Linked Life Data

21139267

Source:http://linkedlifedata.com/resource/pubmed/id/21139267

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2010-12-8
pubmed:abstractText
Salidroside is a phenylpropanoid glycoside isolated from Rhodiola rosea L., a traditional Chinese medicinal plant, and has displayed a broad spectrum of pharmacological properties. In this paper, about 18 novel salidroside analogues were prepared through Koenigs-Knorr method, the effects of these compounds over PC12 was assessed with the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. The novel compounds differ in the substituents attached to the benzene ring or in the glycosyl donor. According to the data, compounds (3,5-dimethoxyphenyl)methyl ?-D-glucopyranoside and (3,5-dimethoxyphenyl)methyl ?-D-galactopyranoside with methoxy group at 3 and 5-positions of the benzene ring were the most viability at concentration of 300 µmol/l and 60 µmol/l, respectively.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1347-5223
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1627-9
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Synthesis, biological activity of salidroside and its analogues.
pubmed:affiliation
Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't