Linked Life Data

21139246

Source:http://linkedlifedata.com/resource/pubmed/id/21139246

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2010-12-8
pubmed:abstractText
We recently reported that some dibenzoylmethane (DBM) derivatives have a protective effect against endoplasmic reticulum (ER) stress and inhibit nuclear factor kappa B (NF-?B). The aim of this study was to evaluate the effect of DBM derivatives against dextran sulfate sodium (DSS)-induced colitis in mice. The DBM derivatives used in this study were 4,4'-dibromodibenzoylmethane that protects against ER stress, and, 4,4'-dichlorodibenzoylmethane that protects against ER stress and inhibits NF-?B. In each group, the presence of faecal occult blood, the disease activity index score (DAI score) and intestinal length were examined. Both of the DBM derivatives with protective effects against ER stress significantly improved occult bleeding of the colitis induced by DSS. The 4,4'-dichlorodibenzoylmethane significantly reduced the DAI score and inhibited the shortening of colon length, but the 4,4'-dibromodibenzoylmethane did not. These findings suggest that both the protective effect against ER stress and inhibitory effect on NF-?B are needed in the treatment of DSS-induced colitis. Therefore, the effect of 4,4'-dichlorodibenzoylmethane maybe beneficial in the therapeutic regulation of ulcerative colitis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1347-5215
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2029-32
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Efficacy of dibenzoylmethane derivatives in protecting against endoplasmic reticulum stress and inhibiting nuclear factor kappa B on dextran sulfate sodium induced colitis in mice.
pubmed:affiliation
Meiji Dairies Corporation, Kanagawa, Japan. RIKA_MURAKAMI@MEIJI-MILK.COM
pubmed:publicationType
Journal Article