rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
10
|
pubmed:dateCreated |
2010-12-8
|
pubmed:abstractText |
The effect of hydrophobic octadecyl groups on pH-dependent aggregation behavior of polyaspartammide derivatives was studied. A series of pH-sensitive amphiphilic polymers with different degrees of octaceylamine (C18) substitution were synthesized through a successive graft reaction of octaceylamine, O-(2-aminoethyl)-O'-methylpolyethylene glycol, and 1-(3-aminopropyl)imidazole on polysuccinimide. Micelle-like nano-aggregates were formed in aqueous solution at pH > 6.8 and they showed different pH dependent aggregation behavior according to degree of substitution (DS) of the hydrophobic C18 chains. These polymers will have a potential application as carriers for pH-sensitive drug release in anticancer or intracellular delivery systems.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
1533-4880
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
10
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
6986-91
|
pubmed:meshHeading |
pubmed-meshheading:21137839-Amines,
pubmed-meshheading:21137839-Drug Delivery Systems,
pubmed-meshheading:21137839-Hydrogen-Ion Concentration,
pubmed-meshheading:21137839-Hydrophobic and Hydrophilic Interactions,
pubmed-meshheading:21137839-Imidazoles,
pubmed-meshheading:21137839-Micelles,
pubmed-meshheading:21137839-Microscopy, Electron, Scanning,
pubmed-meshheading:21137839-Molecular Weight,
pubmed-meshheading:21137839-Nanoparticles,
pubmed-meshheading:21137839-Nuclear Magnetic Resonance, Biomolecular,
pubmed-meshheading:21137839-Particle Size,
pubmed-meshheading:21137839-Peptides,
pubmed-meshheading:21137839-Polyethylene Glycols,
pubmed-meshheading:21137839-Propanols
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pubmed:year |
2010
|
pubmed:articleTitle |
Effect of hydrophobic octadecyl groups on pH-sensitive aggregation behavior of imidazole-containing polyaspartammide derivatives.
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pubmed:affiliation |
Department of Chemical Engineering, Sungkyunkwan University, Suwon 440-746, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|