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rdf:type |
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lifeskim:mentions |
umls-concept:C0006141,
umls-concept:C0006142,
umls-concept:C0014597,
umls-concept:C0033684,
umls-concept:C0086418,
umls-concept:C0751973,
umls-concept:C0805527,
umls-concept:C1456386,
umls-concept:C1705165,
umls-concept:C2003903,
umls-concept:C2700061
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pubmed:issue |
10-11
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|
pubmed:dateCreated |
2010-12-7
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pubmed:abstractText |
immortalization is one of the first changes in cells undergoing carcinogenic transformation. Proteome profiling of the immortalization-senescence transition is expected to provide insights into the molecular mechanisms of early tumorigenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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|
pubmed:month |
Nov
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pubmed:issn |
1862-8354
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|
pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
816-28
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pubmed:meshHeading |
pubmed-meshheading:21137025-Breast,
pubmed-meshheading:21137025-Breast Neoplasms,
pubmed-meshheading:21137025-Cell Aging,
pubmed-meshheading:21137025-Cell Transformation, Neoplastic,
pubmed-meshheading:21137025-Down-Regulation,
pubmed-meshheading:21137025-Epithelial Cells,
pubmed-meshheading:21137025-Female,
pubmed-meshheading:21137025-Gene Expression Profiling,
pubmed-meshheading:21137025-Humans,
pubmed-meshheading:21137025-MAP Kinase Kinase 3,
pubmed-meshheading:21137025-Proteome,
pubmed-meshheading:21137025-Spectrometry, Mass, Matrix-Assisted Laser...,
pubmed-meshheading:21137025-Tumor Cells, Cultured
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|
pubmed:year |
2010
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pubmed:articleTitle |
Proteome profiling of immortalization-to-senescence transition of human breast epithelial cells identified MAP2K3 as a senescence-promoting protein which is downregulated in human breast cancer.
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pubmed:affiliation |
Karolinska Biomics Center, Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
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pubmed:publicationType |
Journal Article
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