Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
1990-8-2
|
pubmed:abstractText |
A prospective randomized trial was conducted to compare the efficiency of two ovarian stimulation protocols for in vitro fertilization-embryo transfer or gamete intrafallopian transfer. Protocol 1 consisted of clomiphene citrate and human menopausal gonadotropin (hMG) with 55 cycles of 42 patients being evaluated. Protocol 2 had 38 cycles of 34 patients receiving a gonadotropin-releasing hormone agonist (GnRH-a) and hMG. The incidence of a spontaneous luteinizing hormone surge was 38.2% in protocol 1 and 0% in protocol 2. Both protocols had a similar cancellation rate. The total clinical pregnancy rates per oocyte retrieval for patients receiving protocol 1 and protocol 2 were 19.5% and 10.3%, respectively. The difference was not statistically significant. Therefore, as first-line ovulation induction agents, it cannot be concluded that either protocol demonstrates a clear superiority over the other and further trials of the GnRH-a/hMG combination are indicated.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Clomiphene,
http://linkedlifedata.com/resource/pubmed/chemical/Estradiol,
http://linkedlifedata.com/resource/pubmed/chemical/Gonadotropin-Releasing Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Leuprolide,
http://linkedlifedata.com/resource/pubmed/chemical/Luteinizing Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Menotropins
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
|
pubmed:issn |
0015-0282
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
54
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
90-5
|
pubmed:dateRevised |
2007-11-15
|
pubmed:meshHeading |
pubmed-meshheading:2113492-Adult,
pubmed-meshheading:2113492-Clinical Trials as Topic,
pubmed-meshheading:2113492-Clomiphene,
pubmed-meshheading:2113492-Estradiol,
pubmed-meshheading:2113492-Female,
pubmed-meshheading:2113492-Fertilization in Vitro,
pubmed-meshheading:2113492-Follicular Phase,
pubmed-meshheading:2113492-Gamete Intrafallopian Transfer,
pubmed-meshheading:2113492-Gonadotropin-Releasing Hormone,
pubmed-meshheading:2113492-Humans,
pubmed-meshheading:2113492-Leuprolide,
pubmed-meshheading:2113492-Luteinizing Hormone,
pubmed-meshheading:2113492-Menotropins,
pubmed-meshheading:2113492-Prospective Studies,
pubmed-meshheading:2113492-Random Allocation
|
pubmed:year |
1990
|
pubmed:articleTitle |
Evaluation of leuprolide acetate and gonadotropins versus clomiphene citrate and gonadotropins for in vitro fertilization or gamete intrafallopian transfer.
|
pubmed:affiliation |
Department of Obstetrics and Gynecology, New York Hospital-Cornell University Medical Center, New York.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial
|