Linked Life Data

21134654

Source:http://linkedlifedata.com/resource/pubmed/id/21134654

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-12-7
pubmed:abstractText
Intensity-modulated radiation therapy (IMRT) became available to the radiation oncology community in the late 1990s, and its initial applications were to increase conformality of dose to the target, allowing for both dose escalation and decreased radiation to adjacent normal organs. In most disease sites, these continue to be the goals of IMRT. However, for breast cancer, IMRT has emerged with a different endpoint, namely improving dose homogeneity throughout the targeted breast. In 2 recent prospective randomized trials comparing IMRT with "standard" planning, IMRT was associated with a significant decrease in both acute side effects and late fibrosis, which was related directly to dose homogeneity. Better conformality can also be achieved with IMRT; yet because of the unique location of the breast tissue external to the thoracic contents, attempts at "inverse planning" with multiple fields were largely not perceived as "better" plans when treating the breast alone. Research is underway to determine if the use of IMRT for breast or chest wall along with regional lymphatics may improve outcomes over "standard" treatment planning. Additionally, special anatomic situations, such as pectus excavatum, have been shown to benefit from IMRT.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1532-9461
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
51-4
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Intensity-modulated radiation therapy for breast: is it for everyone?
pubmed:affiliation
Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. mccormib@mskcc.org
pubmed:publicationType
Journal Article, Review